Histamine activates pain‐transmitting nerve fibres, releases pain‐related neuropeptides,
and is painful when injected into the skin. Histamine agonists mimic these effects …

The antihistaminic drug levocabastine is a ligand for the low affinity neurotensin receptor
(NTS2). Its intracerebroventricular administration to mice induced a significant analgesia in …

In the present study, effects of intracerebroventricular (icv) administration of histamine,
mepyramine (H1-receptor antagonist) and famotidine (H2-receptor antagonist) have been …

The aim of the present study is to elucidate the confusion that exists in the literature
concerning which receptor subtype is involved in mediating histamine antinociception. To …

We have previously reported that the histaminergic system is involved in the control of pain
perception, and that substances able to enhance histamine brain levels, such as the …

IMPLICATIONS: Histamine receptor antagonists present antinociceptive effects when
administered peripherally. These effects are observed through a nociceptive flinching …

JUSTIFICATIVA E OBJETIVOS: Os receptores de histamina mediam vias nociceptivas
principalmente no sistema nervoso central. Alguns estudos mostraram efeito analgésico de …

The possible role of L-arginine/nitric oxide (L-arginine/NO) pathway in the antinociceptive
activity of thiamine (vitamin B 1 in p-benzoquinone-induced mouse writhing model was …

In this study, effects of chlorpheniramine (H,-receptor blocker), ranitidine (H,-receptor
blocker), morphine (an opioid agonist) and naloxone (an opioid antagonist) in separate and …

Antihistamines provide antagonism to the deleterious effects of histamine by competing for
the histamine receptors. To date, four different histamine receptors have been identified, but …