NF-κB: an essential transcription factor in psoriasis

AM Goldminz, SC Au, N Kim, AB Gottlieb… - Journal of dermatological …, 2013 - Elsevier
Nuclear factor kappa B (NF-κB) is a protein transcription factor that orchestrates
inflammation and other complex biological processes. It is a key regulatory element in a …

Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer

VR Yadav, S Prasad, B Sung, R Kannappan… - Toxins, 2010 - mdpi.com
Traditional medicine and diet has served mankind through the ages for prevention and
treatment of most chronic diseases. Mounting evidence suggests that chronic inflammation …

[HTML][HTML] Daphnetin inhibits proliferation and inflammatory response in human HaCaT keratinocytes and ameliorates imiquimod-induced psoriasis-like skin lesion in …

J Gao, F Chen, H Fang, J Mi, Q Qi, M Yang - Biological Research, 2020 - SciELO Chile
GAO, Jintao et al. Daphnetin inhibits proliferation and inflammatory response in human
HaCaT keratinocytes and ameliorates imiquimod-induced psoriasis-like skin lesion in mice …

Systematic review of complementary and alternative medicine treatments in inflammatory bowel diseases

J Langhorst, H Wulfert, R Lauche… - Journal of Crohn's …, 2015 - academic.oup.com
Objective: We performed a systematic review for Complementary and Alternative Medicine
[CAM] as defined by the National Institute of Health in Inflammatory Bowel Disease [IBD], ie …

The journey of boswellic acids from synthesis to pharmacological activities

EA Ragab, MF Abd El-Wahab, AS Doghish… - Naunyn-schmiedeberg's …, 2024 - Springer
There has been a lot of interest in using naturally occurring substances to treat a wide
variety of chronic disorders in recent years. From the gum resin of Boswellia serrata and …

Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer

MK Shanmugam, AH Nguyen, AP Kumar, BKH Tan… - Cancer letters, 2012 - Elsevier
Over the last two decades, extensive research on plant-based medicinal compounds has
revealed exciting and important pharmacological properties and activities of triterpenoids …

Boswellic acids and their role in chronic inflammatory diseases

HPT Ammon - Anti-inflammatory Nutraceuticals and Chronic Diseases, 2016 - Springer
Boswellic acids, which are pentacyclic triterpenes belong to the active pharmacological
compounds of the oleogum resin of different Boswellia species. In the resin, more than 12 …

Molecular mechanisms and management of a cutaneous inflammatory disorder: psoriasis

YR Woo, DH Cho, HJ Park - International Journal of Molecular Sciences, 2017 - mdpi.com
Psoriasis is a complex chronic inflammatory cutaneous disorder. To date, robust molecular
mechanisms of psoriasis have been reported. Among diverse aberrant immunopathogenetic …

[HTML][HTML] IκB kinase β (IKKβ): Structure, transduction mechanism, biological function, and discovery of its inhibitors

J Zhang, R Zhang, W Li, XC Ma, F Qiu… - International Journal of …, 2023 - ncbi.nlm.nih.gov
The effective approach to discover innovative drugs will ask natural products for answers
because of their complex and changeable structures and multiple biological activities …

Chronic inflammation and cancer: potential chemoprevention through nuclear factor kappa B and p53 mutual antagonism

S Pal, A Bhattacharjee, A Ali, NC Mandal… - Journal of …, 2014 - Springer
Activation of nuclear factor-kappa B (NF-κ B) as a mechanism of host defense against
infection and stress is the central mediator of inflammatory responses. A normal (acute) …