The helix-turn-helix (HTH) domain is a common denominator in basal and specific
transcription factors from the three super-kingdoms of life. At its core, the domain comprises …

The bacterial chromosome must be compacted more than 1,000-fold to fit into the
compartment in which it resides. How it is condensed, organized and ultimately segregated …

To estimate the minimal gene set required to sustain bacterial life in nutritious conditions, we
carried out a systematic inactivation of Bacillus subtilis genes. Among≈ 4,100 genes of the …

SMC condensin complexes play a central role in compacting and resolving replicated
chromosomes in virtually all organisms, yet how they accomplish this remains elusive. In …

Spatial organization is a hallmark of all living systems. Even bacteria, the smallest forms of
cellular life, display defined shapes and complex internal organization, showcasing a highly …

Structural maintenance of chromosomes (SMC) proteins are ubiquitous in organisms from
bacteria to humans, and function as core components of the condensin and cohesin …

Background In recent years there has been an increasing problem with Staphylococcus
aureus strains that are resistant to treatment with existing antibiotics. An important starting …

Structural maintenance of chromosomes (SMC) proteins are chromosomal ATPases, highly
conserved from bacteria to humans, that play fundamental roles in many aspects of higher …

Proper chromosome segregation during cell division is essential in all domains of life. In the
majority of bacterial species, faithful chromosome segregation is mediated by the tripartite …

Proper segregation of DNA replication products is essential in all cells. In Bacillus subtilis,
two protein complexes have been implicated in this process: the ParAB homologs, Soj and …