The tumor microenvironment (TME) plays a central role in cancer development and
progression. It represents a complex network of cancer cell (sub-) clones and a variety of …

Hanahan and Weinberg have proposed 10 organizing principles that enable growth and
metastatic dissemination of cancer cells. These distinctive and complementary capabilities …

The clinical benefit conferred by vascular endothelial growth factors (VEGF)-targeted
therapies is variable, and tumors from treated patients eventually reinitiate growth. Here, we …

Pectin is a constituent of the cell walls of fruits and vegetables, and provides an important
source of dietary fibre, as well as being a functional ingredient in processed foods. In …

The concept of antiangiogenic therapy in cancer treatment has led to the approval of
different agents, most of them targeting the well known vascular endothelial growth factor …

Abstract Activated Leukocyte Cell Adhesion Molecule (ALCAM/CD166) is a glycoprotein
involved in homotypic and heterotypic cell adhesion. ALCAM can be proteolytically cleaved …

Angiogenesis is a critical, fine-tuned, multi-staged biological process. Tip-stalk cell selection
and shuffling are the building blocks of sprouting angiogenesis. Accumulated evidences …

Endothelial-to-mesenchymal transition (EndMT) is a process that encompasses extensive
transcriptional reprogramming of activated endothelial cells leading to a shift toward …

Highlights•Galectins engage a number of glycosylated immune checkpoint
receptors.•Galectins alter T-cell and NK-cell activation, signaling and survival.•Galectins …

Kaposi's sarcoma (KS), a multifocal vascular neoplasm linked to human herpesvirus-8 (HHV-
8/KS-associated herpesvirus [KSHV]) infection, is the most common AIDS-associated …