An active inference approach to interoceptive psychopathology

MP Paulus, JS Feinstein… - Annual review of clinical …, 2019 - annualreviews.org
Interoception refers to the process by which the nervous system senses and integrates
signals originating from within the body, providing a momentary mapping of the body's …

Can interoception improve the pragmatic search for biomarkers in psychiatry?

SS Khalsa, RC Lapidus - Frontiers in psychiatry, 2016 - frontiersin.org
Disrupted interoception is a prominent feature of the diagnostic classification of several
psychiatric disorders. However, progress in understanding the interoceptive basis of these …

Dissociation and emotion regulation strategies: A meta-analytic review

M Cavicchioli, A Scalabrini, G Northoff, C Mucci… - Journal of Psychiatric …, 2021 - Elsevier
Objective Clinical and neurobiological models posited that dissociative mechanisms might
affect processes involved in emotional generation and regulation. However, there is a lack of …

Clinical neurocardiology defining the value of neuroscience‐based cardiovascular therapeutics

K Shivkumar, OA Ajijola, I Anand… - The Journal of …, 2016 - Wiley Online Library
The autonomic nervous system regulates all aspects of normal cardiac function, and is
recognized to play a critical role in the pathophysiology of many cardiovascular diseases. As …

Interoception and Mental Health

SS Khalsa, C Verdonk - Interoception: A Comprehensive Guide, 2024 - Springer
Interoception is crucial for human health as it constitutes the afferent component of the brain-
body feedback loop that is essential for maintaining physiological equilibrium. Disruption in …

[HTML][HTML] The amygdala is a chemosensor that detects carbon dioxide and acidosis to elicit fear behavior

AE Ziemann, JE Allen, NS Dahdaleh, II Drebot… - Cell, 2009 - cell.com
The amygdala processes and directs inputs and outputs that are key to fear behavior.
However, whether it directly senses fear-evoking stimuli is unknown. Because the amygdala …

Fear and panic in humans with bilateral amygdala damage

JS Feinstein, C Buzza, R Hurlemann, RL Follmer… - Nature …, 2013 - nature.com
Decades of research have highlighted the amygdala's influential role in fear. We found that
inhalation of 35% CO2 evoked not only fear, but also panic attacks, in three rare patients …

[HTML][HTML] Amygdala-driven apnea and the chemoreceptive origin of anxiety

JS Feinstein, D Gould, SS Khalsa - Biological psychology, 2022 - Elsevier
Although the amygdala plays an important part in the pathogenesis of anxiety and
generation of exteroceptive fear, recent discoveries have challenged the directionality of this …

Perceptual insensitivity to the modulation of interoceptive signals in depression, anxiety, and substance use disorders

R Smith, JS Feinstein, R Kuplicki, KL Forthman… - Scientific reports, 2021 - nature.com
This study employed a series of heartbeat perception tasks to assess the hypothesis that
cardiac interoceptive processing in individuals with depression/anxiety (N= 221), and …

Altered fear behavior in aeroallergen house dust mite exposed C57Bl/6 mice: A model of Th2-skewed airway inflammation

E Allgire, RA Ahlbrand, N Nawreen, A Ajmani… - Neuroscience, 2023 - Elsevier
There is a growing interest for studying the impact of chronic inflammation, particularly lung
inflammation, on the brain and behavior. This includes asthma, a chronic inflammatory …