The viral protein NSP1 acts as a ribosome gatekeeper for shutting down host translation and fostering SARS-CoV-2 translation
A Tidu, A Janvier, L Schaeffer, P Sosnowski, L Kuhn… - Rna, 2021 - rnajournal.cshlp.org
SARS-CoV-2 coronavirus is responsible for the Covid-19 pandemic. In the early phase of
infection, the single-strand positive RNA genome is translated into nonstructural proteins …
infection, the single-strand positive RNA genome is translated into nonstructural proteins …
An insight into SARS-CoV-2 membrane protein interaction with spike, envelope, and nucleocapsid proteins
Intraviral protein–protein interactions are crucial for replication, pathogenicity, and viral
assembly. Among these, virus assembly is a critical step as it regulates the arrangements of …
assembly. Among these, virus assembly is a critical step as it regulates the arrangements of …
Conformational dynamics of 13 amino acids long NSP11 of SARS-CoV-2 under membrane mimetics and different solvent conditions
The intrinsically disordered proteins/regions (IDPs/IDPRs) are known to be responsible for
multiple cellular processes and are associated with many chronic diseases. In viruses, the …
multiple cellular processes and are associated with many chronic diseases. In viruses, the …
Modelling studies reveal the importance of the C-terminal inter motif loop of NSP1 as a promising target site for drug discovery and screening of potential …
D Prabhu, S Rajamanikandan, M Sureshan… - Journal of Molecular …, 2021 - Elsevier
COVID-19 pandemic causative SARS-CoV-2 coronavirus is still rapid in progression and
transmission even after a year. Understanding the viral transmission and impeding the …
transmission even after a year. Understanding the viral transmission and impeding the …
Extended ensemble simulations of a SARS-CoV-2 nsp1–5'-UTR complex
Nonstructural protein 1 (nsp1) of severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) is a 180-residue protein that blocks translation of host mRNAs in SARS-CoV-2 …
CoV-2) is a 180-residue protein that blocks translation of host mRNAs in SARS-CoV-2 …
[HTML][HTML] Microsecond simulations and CD spectroscopy reveals the intrinsically disordered nature of SARS-CoV-2 spike-C-terminal cytoplasmic tail (residues 1242 …
All available SARS-CoV-2 spike protein crystal and cryo-EM structures have shown missing
electron densities for cytosolic C-terminal regions (CTR). Generally, the missing electron …
electron densities for cytosolic C-terminal regions (CTR). Generally, the missing electron …
Zika virus NS4A N-Terminal region (1-48) acts as a cofactor for inducing NTPase activity of NS3 helicase but not NS3 protease
Abstract Among Flaviviridae, in West Nile virus (WNV) and Hepatitis C virus (HCV), the non-
structural protein NS4A modulates the NTPase activity of viral helicases during nucleic acid …
structural protein NS4A modulates the NTPase activity of viral helicases during nucleic acid …
NSP 11 of SARS-CoV-2 is an intrinsically disordered protein
K Gadhave, P Kumar, A Kumar, T Bhardwaj, N Garg… - BioRxiv, 2020 - biorxiv.org
The intrinsically disordered proteins/regions (IDPs/IDPRs) are known to be responsible for
multiple cellular processes and are associated with many chronic diseases. In viruses, the …
multiple cellular processes and are associated with many chronic diseases. In viruses, the …
Modeling SARS-CoV-2 nsp1–5'-UTR complex via the extended ensemble simulations
Abstract Nonstructural protein 1 (nsp1) of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) is a 180-residue protein that blocks the translation of SARS-CoV-2 infected …
(SARS-CoV-2) is a 180-residue protein that blocks the translation of SARS-CoV-2 infected …
Environmental dependence of the structure of the c-terminal domain of the SARS-CoV-2 envelope protein
The SARS-CoV-2 envelope protein (E) is involved in a broad spectrum of functions in the
cycle of the virus, including assembly, budding, envelope formation, and pathogenesis. To …
cycle of the virus, including assembly, budding, envelope formation, and pathogenesis. To …