Small-molecule drug discovery has traditionally focused on occupancy of a binding site that
directly affects protein function, and this approach typically precludes targeting proteins that …

Currently, a new technology termed PROTAC, proteolysis targeting chimera, has been
developed for inducing the protein degradation by a targeting molecule. This technology …

A Hybrid drug which comprises the incorporation of two drug pharmacophores in one single
molecule are basically designed to interact with multiple targets or to amplify its effect …

Intermolecular cross-coupling of terminal olefins with secondary amines to form complex
tertiary amines—a common motif in pharmaceuticals—remains a major challenge in …

Genetic loss of function analysis is a powerful method for the study of protein function.
However, some cell biological questions are difficult to address using traditional genetic …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

Receptor‐mediated drug delivery presents an opportunity to enhance therapeutic efficiency
by accumulating drug within the tissue of interest and reducing undesired, off‐target effects …

Natural products play an important role in the development of drugs, especially for the
treatment of infections and cancer, as well as immunosuppressive compounds. However …

Breast cancer, a most common malignancy in women, was known to be associated with
steroid hormone estrogen. The discovery of estrogen receptor (ER) gave us not only a …

Heat shock proteins (Hsp) form the most ancient defense system in all living organisms on
earth. These proteins act as molecular chaperones by helping in the refolding of misfolded …