[HTML][HTML] Body fatness associations with cancer: evidence from recent epidemiological studies and future directions

SC Larsson, N Spyrou, CS Mantzoros - Metabolism, 2022 - Elsevier
This narrative review highlights current evidence linking greater body fatness to risk of
various cancers, with focus on evidence from recent large cohort studies and pooled …

Colorectal cancer: from risk factors to oncogenesis

VA Ionescu, G Gheorghe, N Bacalbasa, AL Chiotoroiu… - Medicina, 2023 - mdpi.com
Colorectal cancer is the second leading cause of cancer-related mortality worldwide.
Numerous pathophysiological mechanisms, such as abnormal cell proliferation, cell …

Gastrointestinal consequences of type 2 diabetes mellitus and impaired glycemic homeostasis: a mendelian randomization study

J Chen, S Yuan, T Fu, X Ruan, J Qiao, X Wang… - Diabetes …, 2023 - Am Diabetes Assoc
OBJECTIVE We conducted a Mendelian randomization (MR) study to examine the
associations of type 2 diabetes and glycemic traits with gastrointestinal diseases (GDs) …

Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts

JA Rothwell, J Bešević, N Dimou, M Breeur, N Murphy… - BMC medicine, 2023 - Springer
Background Amino acid metabolism is dysregulated in colorectal cancer patients; however,
it is not clear whether pre-diagnostic levels of amino acids are associated with subsequent …

Atherosclerosis, diabetes mellitus, and cancer: common epidemiology, shared mechanisms, and future management

V Katsi, I Papakonstantinou, K Tsioufis - International Journal of …, 2023 - mdpi.com
The involvement of cardiovascular disease in cancer onset and development represents a
contemporary interest in basic science. It has been recognized, from the most recent …

Incident early-and later-onset type 2 diabetes and risk of early-and later-onset cancer: prospective cohort study

Y Zhang, M Song, Y Cao, AH Eliassen… - Diabetes …, 2023 - Am Diabetes Assoc
OBJECTIVE We evaluated prospectively the association between incident early-onset
(diagnosed before 40 years of age) and later-onset type 2 diabetes and early-onset …

Morning chronotype and digestive tract cancers: Mendelian randomization study

S Yuan, AM Mason, OE Titova… - … journal of cancer, 2023 - Wiley Online Library
Morning chronotype has been associated with a reduced risk of prostate and breast cancer.
However, few studies have examined whether chronotype is associated with digestive tract …

The role of gut microbiota and drug interactions in the development of colorectal cancer

J Wu, C Xia, C Liu, Q Zhang, C Xia - Frontiers in Pharmacology, 2023 - frontiersin.org
The human gut microbiota is a complex ecosystem regulating the host's environmental
interaction. The same functional food or drug may have varying bioavailability and distinct …

[HTML][HTML] Obesity-associated colorectal cancer

L Gonzalez-Gutierrez, O Motiño, D Barriuso… - International Journal of …, 2024 - mdpi.com
Colorectal cancer (CRC) affects approximately 2 million people worldwide. Obesity is the
major risk factor for CRC. In addition, obesity contributes to a chronic inflammatory stage that …

Risk Assessment for Gastrointestinal Diseases via Clinical Dimension and Genome-Wide Polygenic Risk Scores of Type 2 Diabetes: A Population-Based Cohort …

T Fu, Y Sun, S Lu, J Zhao, L Dan, W Shi, J Chen… - Diabetes …, 2024 - Am Diabetes Assoc
OBJECTIVE We aimed to evaluate whether individuals with type 2 diabetes (T2D) were at
higher risk of developing a wide range of gastrointestinal diseases based on a population …