Minimum complexity drives regulatory logic in Boolean models of living systems

A Subbaroyan, OC Martin, A Samal - PNAS nexus, 2022 - academic.oup.com
The properties of random Boolean networks have been investigated extensively as models
of regulation in biological systems. However, the Boolean functions (BFs) specifying the …

On Networks and their Applications: Stability of Gene Regulatory Networks and Gene Function Prediction using Autoencoders

H Coban - arXiv preprint arXiv:2408.07064, 2024 - arxiv.org
We prove that nested canalizing functions are the minimum-sensitivity Boolean functions for
any activity ratio and we determine the functional form of this boundary which has a …

Canalization and competition: the cornerstone of genetic network's dynamic stability and evolution

Y Yao, ZG Huang, D Pei - bioRxiv, 2024 - biorxiv.org
Grasping the fundamental dynamic property is a crucial approach for understanding living
systems. Here we conduct a comprehensive study into the relationship between regulatory …

Critical dynamics in biological Boolean networks follows from symmetric response to input genes

H ÇOBAN, A KABAKÇIOĞLU - Turkish Journal of Physics, 2022 - journals.tubitak.gov.tr
A recent observation on an extensive collection of biological gene regulatory networks
suggests that the regulatory dynamics is tuned to remain close to the order-chaos boundary …

Elucidating and leveraging design principles towards realistic Boolean models of gene regulatory networks [HBNI Th246]

S Ajay - 2024 - imsc.res.in
Cells make decisions based on underlying gene regulatory networks (GRNs). GRNs may be
modeled as a Boolean network (BN) in which nodes and directed edges represent genes or …