Nanoparticle immunogenicity and antigenicity have been under investigation for many
years. During the past decade, significant progress has been made in understanding what …

At the time of the first issue of the Journal of Controlled Release (JCR), polymeric drugs,
polymer–drug and protein conjugates and block copolymer micelles carrying bound drugs …

The use of coronavirus disease 2019 (COVID-19) vaccines will play the major role in
helping to end the pandemic that has killed millions worldwide. COVID-19 vaccines have …

Limited therapeutic efficacy of polyethylene glycol-conjugated (PEGylated) protein drugs
has been recently reported in animals and human following repeat injections. Since there …

Modifying the surface of nanoparticles with polyethylene glycol (PEG) is a commonly used
approach for improving the in vitro stability of nanoparticles such as liposomes and …

Polyethylene glycol (PEG), a polyether compound, is available in molecular weights from∼
300 g/mol to∼ 10,000,000 g/mol. In the molecular weight range of∼ 750 to∼ 5000, PEG is …

Aptamers, synthetic single-strand oligonucleotides that are similar in function to antibodies,
are promising as therapeutics because of their minimal side effects. However, the stability …

Liposomes are known to activate the complement (C) system, which can lead in vivo to a
hypersensitivity syndrome called C activation-related pseudoallergy (CARPA). CARPA has …

The advent of COVID-19 vaccines will play a major role in helping to end the pandemic that
has killed millions worldwide. Vaccine candidates have demonstrated robust humoral …

The conjugation of poly (ethylene glycol)(PEG) to therapeutic proteins or nanoparticles is a
widely used pharmaceutical strategy to improve their therapeutic efficacy. However …