MALAT1: A key regulator in lung cancer pathogenesis and therapeutic targeting
Lung cancer remains a formidable global health burden, necessitating a comprehensive
understanding of the underlying molecular mechanisms driving its progression. Recently …
understanding of the underlying molecular mechanisms driving its progression. Recently …
Nuclear long noncoding RNAs: key regulators of gene expression
A significant portion of the human genome encodes genes that transcribe long nonprotein-
coding RNAs (lncRNAs). A large number of lncRNAs localize in the nucleus, either enriched …
coding RNAs (lncRNAs). A large number of lncRNAs localize in the nucleus, either enriched …
Potential of long non‐coding RNAs in cancer patients: from biomarkers to therapeutic targets
S Chandra Gupta… - International journal of …, 2017 - Wiley Online Library
Because of high specificity and easy detection in the tissues, serum, plasma, urine and
saliva, interest in exploring the potential of long non‐coding RNAs (lncRNAs) in cancer …
saliva, interest in exploring the potential of long non‐coding RNAs (lncRNAs) in cancer …
Drugging the lncRNA MALAT1 via LNA gapmeR ASO inhibits gene expression of proteasome subunits and triggers anti-multiple myeloma activity
The biological role and therapeutic potential of long non-coding RNAs (lncRNAs) in multiple
myeloma (MM) are still to be investigated. Here, we studied the functional significance and …
myeloma (MM) are still to be investigated. Here, we studied the functional significance and …
Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation
R Chen, Y Liu, H Zhuang, B Yang, K Hei… - Nucleic acids …, 2017 - academic.oup.com
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a broadly expressed
lncRNA involved in many aspects of cellular processes. To further delineate the underlying …
lncRNA involved in many aspects of cellular processes. To further delineate the underlying …
Gene regulation of mammalian long non-coding RNA
H Bunch - Molecular Genetics and Genomics, 2018 - Springer
RNA pol ymerase II (Pol II) transcribes two classes of RNAs, protein-coding and n on-protein-
c oding (ncRNA) genes. ncRNAs are also synthesized by RNA pol ymerases I and III (Pol I …
c oding (ncRNA) genes. ncRNAs are also synthesized by RNA pol ymerases I and III (Pol I …
MALAT1: A long non‑coding RNA highly associated with human cancers
M Zhao, S Wang, Q Li, Q Ji, P Guo… - Oncology …, 2018 - spandidos-publications.com
Metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1), a well‑known lncRNA
associated with numerous diseases, particularly cancer, has received increased attention …
associated with numerous diseases, particularly cancer, has received increased attention …
Targeted nanocomplex carrying siRNA against MALAT1 sensitizes glioblastoma to temozolomide
SS Kim, JB Harford, M Moghe, A Rait… - Nucleic acids …, 2018 - academic.oup.com
Intrinsic therapeutic resistance especially in cancer stem cells (CSCs) together with
extensive tumor cell infiltration and restricted permeation of the blood-brain barrier (BBB) by …
extensive tumor cell infiltration and restricted permeation of the blood-brain barrier (BBB) by …
Linc-ROR promotes osteogenic differentiation of mesenchymal stem cells by functioning as a competing endogenous RNA for miR-138 and miR-145
Long noncoding RNAs (lncRNAs), which serve as important and powerful regulators of
various biological activities, have gained widespread attention in recent years. Emerging …
various biological activities, have gained widespread attention in recent years. Emerging …
Malat1 long noncoding RNA regulates inflammation and leukocyte differentiation in experimental autoimmune encephalomyelitis
In this study, we investigated the contributions of the MALAT1 long noncoding RNA to
autoimmune neuroinflammation in central nervous system tissues from patients with multiple …
autoimmune neuroinflammation in central nervous system tissues from patients with multiple …