Background Genetic polymorphisms are known to influence outcomes with phenytoin yet
effects in the Middle East and North Africa region are poorly understood. Objectives The …

Objective: To analyze the correlation between VKORC1 gene polymorphisms and warfarin
maintenance dosage, as well as the correlation of dosage of warfarin with age and ethnicity …

What is known and objective Despite an apparently sound pharmacological basis, clinical
studies of genotype‐guided warfarin dosing have yielded mixed and conflicting results …

Warfarin is a readily available anticoagulant used worldwide in a variety of clinical
scenarios. Patients who need more than 15 mg/day are considered to be warfarin resistant …

Warfarin is the most widely prescribed anticoagulant drugs. Cytochrome P450-2C9
(CYP2C9) and vitamin K epoxide reductase-oxidaxe complex subunit 1 (VKORC1) …

Objective: The aim was to investigate the frequency of genetic polymorphisms of cytochrome
P4502C9 (CYP2C9) and vitamin K epoxide reductase complex subunit1 (VKORC1) and …

Warfarin is a common oral anticoagulant, but the dose needed for each patient can vary by
as much as 20 times due to both environmental and genetic factors. Some of the most …

Цель исследования-изучить и проанализировать взаимосвязи показателей гемостаза с
носительством полиморфизмов, ассоциированных с повышенным риском тромбозов …

Objective: Warfarin is one of the most widely used anticoagulants worldwide. Some patients
need> 15 mg/day of warfarin to get their therapeutic international normalized ratio (INR) …

Warfarin resistance is a rare condition and its prevalence is less than 0.1%[1]. It is defined as
a daily Coumadin requirement of more than 15mg or a weekly requirement of more than …