Tumor-on-a-chip: from bioinspired design to biomedical application

X Liu, J Fang, S Huang, X Wu, X Xie, J Wang… - Microsystems & …, 2021 - nature.com
Cancer is one of the leading causes of human death, despite enormous efforts to explore
cancer biology and develop anticancer therapies. The main challenges in cancer research …

Three-dimensional cell cultures in drug discovery and development

Y Fang, RM Eglen - Slas discovery: Advancing Life Sciences …, 2017 - journals.sagepub.com
The past decades have witnessed significant efforts toward the development of three-
dimensional (3D) cell cultures as systems that better mimic in vivo physiology. Today, 3D …

Second-generation lung-on-a-chip with an array of stretchable alveoli made with a biological membrane

P Zamprogno, S Wüthrich, S Achenbach… - Communications …, 2021 - nature.com
The air-blood barrier with its complex architecture and dynamic environment is difficult to
mimic in vitro. Lung-on-a-chips enable mimicking the breathing movements using a thin …

Organ‐on‐a‐Chip Systems: microengineering to biomimic living systems

F Zheng, F Fu, Y Cheng, C Wang, Y Zhao, Z Gu - Small, 2016 - Wiley Online Library
“Organ‐on‐a‐chip” systems integrate microengineering, microfluidic technologies, and
biomimetic principles to create key aspects of living organs faithfully, including critical …

3D printing: an emerging tool for novel microfluidics and lab-on-a-chip applications

AA Yazdi, A Popma, W Wong, T Nguyen, Y Pan… - Microfluidics and …, 2016 - Springer
In the past few years, 3D printing technology has witnessed an explosive growth,
penetrating various aspects of our lives. Current best-in-class 3D printers can fabricate …

3D printing techniques and their applications to organ-on-a-chip platforms: a systematic review

V Carvalho, I Gonçalves, T Lage, RO Rodrigues… - Sensors, 2021 - mdpi.com
Three-dimensional (3D) in vitro models, such as organ-on-a-chip platforms, are an emerging
and effective technology that allows the replication of the function of tissues and organs …

Electrical and mechanical stimulation of cardiac cells and tissue constructs

WL Stoppel, DL Kaplan, LD Black III - Advanced drug delivery reviews, 2016 - Elsevier
The field of cardiac tissue engineering has made significant strides over the last few
decades, highlighted by the development of human cell derived constructs that have shown …

Engineering anastomosis between living capillary networks and endothelial cell-lined microfluidic channels

X Wang, DTT Phan, A Sobrino, SC George… - Lab on a Chip, 2016 - pubs.rsc.org
This paper reports a method for generating an intact and perfusable microvascular network
that connects to microfluidic channels without appreciable leakage. This platform …

Dielectrophoresis for biomedical sciences applications: A review

N Abd Rahman, F Ibrahim, B Yafouz - Sensors, 2017 - mdpi.com
Dielectrophoresis (DEP) is a label-free, accurate, fast, low-cost diagnostic technique that
uses the principles of polarization and the motion of bioparticles in applied electric fields …

Medium throughput breathing human primary cell alveolus-on-chip model

JD Stucki, N Hobi, A Galimov, AO Stucki… - Scientific reports, 2018 - nature.com
Organs-on-chips have the potential to improve drug development efficiency and decrease
the need for animal testing. For the successful integration of these devices in research and …