Influenza virus: dealing with a drifting and shifting pathogen

H Kim, RG Webster, RJ Webby - Viral immunology, 2018 - liebertpub.com
Numerous modern technological and scientific advances have changed the vaccine
industry. However, nearly 70 years of influenza vaccine usage have passed without …

Zoonotic potential of influenza A viruses: a comprehensive overview

A Mostafa, EM Abdelwhab, TC Mettenleiter, S Pleschka - Viruses, 2018 - mdpi.com
Influenza A viruses (IAVs) possess a great zoonotic potential as they are able to infect
different avian and mammalian animal hosts, from which they can be transmitted to humans …

[HTML][HTML] Elevated glucose levels favor SARS-CoV-2 infection and monocyte response through a HIF-1α/glycolysis-dependent axis

AC Codo, GG Davanzo, L de Brito Monteiro… - Cell metabolism, 2020 - cell.com
COVID-19 can result in severe lung injury. It remained to be determined why diabetic
individuals with uncontrolled glucose levels are more prone to develop the severe form of …

A human isolate of bovine H5N1 is transmissible and lethal in animal models

C Gu, T Maemura, L Guan, AJ Eisfeld, A Biswas… - Nature, 2024 - nature.com
Abstract The outbreak of clade 2.3. 4.4 b highly pathogenic avian influenza viruses of the
H5N1 subtype (HPAI H5N1) in dairy cattle in the USA has so far resulted in spillover …

The mechanism of resistance to favipiravir in influenza

DH Goldhill, AJW Te Velthuis… - Proceedings of the …, 2018 - National Acad Sciences
Favipiravir is a broad-spectrum antiviral that has shown promise in treatment of influenza
virus infections. While emergence of resistance has been observed for many antiinfluenza …

Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets

M Imai, T Watanabe, M Hatta, SC Das, M Ozawa… - Nature, 2012 - nature.com
Highly pathogenic avian H5N1 influenza A viruses occasionally infect humans, but currently
do not transmit efficiently among humans. The viral haemagglutinin (HA) protein is a known …

The 1918 influenza pandemic: 100 years of questions answered and unanswered

JK Taubenberger, JC Kash, DM Morens - Science translational …, 2019 - science.org
The 2018–2019 period marks the centennial of the “Spanish” influenza pandemic, which
caused at least 50 million deaths worldwide. The unprecedented nature of the pandemic's …

A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine

NC Wu, SJ Zost, AJ Thompson, D Oyen… - PLoS …, 2017 - journals.plos.org
The effectiveness of the annual influenza vaccine has declined in recent years, especially
for the H3N2 component, and is a concern for global public health. A major cause for this …

The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza

M Morita, K Kuba, A Ichikawa, M Nakayama, J Katahira… - Cell, 2013 - cell.com
Influenza A viruses are a major cause of mortality. Given the potential for future lethal
pandemics, effective drugs are needed for the treatment of severe influenza such as that …

Emergence and pandemic potential of swine-origin H1N1 influenza virus

G Neumann, T Noda, Y Kawaoka - Nature, 2009 - nature.com
Influenza viruses cause annual epidemics and occasional pandemics that have claimed the
lives of millions. The emergence of new strains will continue to pose challenges to public …