[HTML][HTML] Impact of heavy metals on the environment and human health: Novel therapeutic insights to counter the toxicity

S Mitra, AJ Chakraborty, AM Tareq, TB Emran… - Journal of King Saud …, 2022 - Elsevier
Heavy metals are well-known environmental pollutants owing to their toxicity, longevity in
the atmosphere, and ability to accumulate in the human body via bioaccumulation. The …

[HTML][HTML] Benefits and adverse effects of histidine supplementation

AE Thalacker-Mercer, ME Gheller - The Journal of nutrition, 2020 - Elsevier
Histidine is a nutritionally essential amino acid with many recognized benefits to human
health, while circulating concentrations of histidine decline in pathologic conditions [eg …

Effects of sinapic acid on lead acetate‐induced oxidative stress, apoptosis and inflammation in testicular tissue

SÇ Tuncer, SA Akarsu, S Küçükler, C Gür… - Environmental …, 2023 - Wiley Online Library
In this study, the effect of lead acetate (PbAc) and sinapic acid (SNP) administration on
oxidative stress, apoptosis, inflammation, sperm quality and histopathology in testicular …

[HTML][HTML] Mitochondrial dysfunction and oxidative stress are involved in the mechanism of methotrexate-induced renal injury and electrolytes imbalance

R Heidari, A Ahmadi, H Mohammadi… - Biomedicine & …, 2018 - Elsevier
Methotrexate is a folate analog used against a wide range of diseases including
malignancies and autoimmune disorders. On the other hand, clinical use of the MTX is …

The neuroprotective role of coenzyme Q10 against lead acetate-induced neurotoxicity is mediated by antioxidant, anti-inflammatory and anti-apoptotic activities

AO S. Yousef, A A. Fahad, AE Abdel Moneim… - International journal of …, 2019 - mdpi.com
Heavy metal exposure, in lead (Pb) particularly, is associated with severe neuronal
impairment though oxidative stress mediated by reactive oxygen species, and antioxidants …

The mechanisms of arsenic-induced ovotoxicity, ultrastructural alterations, and autophagic related paths: An enduring developmental study in folliculogenesis of mice

MM Ommati, X Shi, H Li, MJ Zamiri, O Farshad… - Ecotoxicology and …, 2020 - Elsevier
Arsenic (As) exerts a wide range of adverse effects on biological systems, including the
reproductive organs in males and females. However, the mechanisms of As-induced …

Pivotal role of carnosine in the modulation of brain cells activity: Multimodal mechanism of action and therapeutic potential in neurodegenerative disorders

G Caruso, F Caraci, RB Jolivet - Progress in neurobiology, 2019 - Elsevier
Abstract Carnosine (β-alanyl-l-histidine), a dipeptide, is an endogenous antioxidant widely
distributed in excitable tissues like muscles and the brain. Although discovered more than a …

Glycine protects the male reproductive system against lead toxicity via alleviating oxidative stress, preventing sperm mitochondrial impairment, improving kinematics of …

MM Ommati, HN Ahmadi, S Sabouri… - Environmental …, 2022 - Wiley Online Library
Lead (Pb) is a highly toxic heavy metal widely dispersed in the environment because of
human industrial activities. Many studies revealed that Pb could adversely affect several …

The crucial role of oxidative stress in non-alcoholic fatty liver disease-induced male reproductive toxicity: the ameliorative effects of Iranian indigenous probiotics

MM Ommati, H Li, A Jamshidzadeh… - Naunyn-Schmiedeberg's …, 2022 - Springer
Several studies have focused on the high potential effects of probiotics on the reproductive
system. However, there is a paucity of information regarding the ameliorative intracellular …

Paternal exposure to arsenic resulted in oxidative stress, autophagy, and mitochondrial impairments in the HPG axis of pubertal male offspring

MM Ommati, R Heidari, RK Manthari, ST Chiranjeevi… - Chemosphere, 2019 - Elsevier
Despite the knowledge of AS-induced reprotoxicity, the literature concerning arsenic trioxide
(As 2 O 3)-induced oxidative stress and consequent intracellular events, like autophagy …