For several decades, multipotent mesenchymal stromal cells (MSCs) have been extensively
studied for their therapeutic potential across a wide range of diseases. In the preclinical …

Osteosarcoma is a rare tumor diagnosed at any age; however younger age is a common risk
factor. In addition, multiple factors are believed to contribute to higher rates of osteosarcoma …

Frequent p53 mutations (mutp53) not only abolish tumor suppressor capacities but confer
various gain-of-function (GOF) activities that impacts molecules and pathways now regarded …

Alcoholic liver disease (ALD) is characterized by steatosis and upregulation of
proinflammatory cytokines, including IL-1β. IL-1β, type I IL-1 receptor (IL-1R1), and IL-1 …

Mesenchymal stem cells (MSCs) are broadly distributed cells that retain postnatal capacity
for self-renewal and multilineage differentiation. MSCs evade immune detection, secrete an …

Stem cell therapy holds the promise to treat degenerative diseases, cancer and repair of
damaged tissues for which there are currently no or limited therapeutic options. The …

Human mesenchymal stem cells (hMSC) aid in tissue maintenance and repair by
differentiating into specialized cell types. Due to this ability, hMSC are currently being …

Stem cells are self-renewing cells that can differentiate into specialized cell type (s).
Pluripotent stem cells, ie embryonic stem cells (ESC) or induced pluripotent stem cells …

Research on stem cells has progressed at a rapid pace and, as might be anticipated, the
results have generated several controversies, a few myths and a change in a major …

Clinical-grade human mesenchymal stromal cells (MSCs) have been expanded in vitro for
tissue engineering or immunoregulatory purposes without standardized culture conditions or …