Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …

Amino acids are fundamental building blocks supporting life. Their role in protein synthesis
is well defined, but they contribute to a host of other intracellular metabolic pathways …

Obesity is associated with impaired intestinal barrier function and dysbiosis of the gut
microbiota. Spermidine, a polyamine that acts as an autophagy inducer, has important …

Autophagy, an essential cellular process that mediates degradation of proteins and
organelles in lysosomes, has been tightly linked to cellular quality control for its role as part …

Caloric restriction and intermittent fasting prolong the lifespan and healthspan of model
organisms and improve human health. The natural polyamine spermidine has been similarly …

Although death is inevitable, individuals have long sought to alter the course of the ageing
process. Indeed, ageing has proved to be modifiable; by intervening in biological systems …

Here, we summarize the current knowledge on eight promising drugs and natural
compounds that have been tested in the clinic: metformin, NAD+ precursors, glucagon-like …

Aging involves the systemic deterioration of all known cell types in most eukaryotes. Several
recently discovered compounds that extend the healthspan and lifespan of model organisms …

Macroautophagy/autophagy is an evolutionarily conserved pathway responsible for clearing
cytosolic aggregated proteins, damaged organelles or invading microorganisms …

Decreased cognitive performance is a hallmark of brain aging, but the underlying
mechanisms and potential therapeutic avenues remain poorly understood. Recent studies …