[HTML][HTML] Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

[HTML][HTML] Broadly neutralizing antibodies to SARS-CoV-2 and other human coronaviruses

Y Chen, X Zhao, H Zhou, H Zhu, S Jiang… - Nature Reviews …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently emerged
pathogenic human coronavirus that belongs to the sarbecovirus lineage of the genus …

Antigenicity and receptor affinity of SARS-CoV-2 BA. 2.86 spike

Q Wang, Y Guo, L Liu, LT Schwanz, Z Li, MS Nair, J Ho… - Nature, 2023 - nature.com
A severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariant, BA.
2.86, has emerged and spread to numerous countries worldwide, raising alarm because its …

[HTML][HTML] The humoral response and antibodies against SARS-CoV-2 infection

H Qi, B Liu, X Wang, L Zhang - Nature Immunology, 2022 - nature.com
Two and a half years into the COVID-19 pandemic, we have gained many insights into the
human antibody response to the causative SARS-CoV-2 virus. In this Review, we …

Durability of mRNA-1273 vaccine–induced antibodies against SARS-CoV-2 variants

A Pegu, SE O'Connell, SD Schmidt, S O'Dell… - Science, 2021 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mutations may diminish
vaccine-induced protective immune responses, particularly as antibody titers wane over …

[HTML][HTML] LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants

K Westendorf, S Žentelis, L Wang, D Foster… - Cell reports, 2022 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-neutralizing monoclonal
antibodies (mAbs) can reduce the risk of hospitalization from coronavirus disease 2019 …

[HTML][HTML] Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies

AJ Greaney, TN Starr, CO Barnes, Y Weisblum… - Nature …, 2021 - nature.com
Monoclonal antibodies targeting a variety of epitopes have been isolated from individuals
previously infected with SARS-CoV-2, but the relative contributions of these different …

[HTML][HTML] Nanotechnology-based strategies against SARS-CoV-2 variants

X Huang, E Kon, X Han, X Zhang, N Kong… - Nature …, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has already infected more
than 500 million people globally (as of May 2022), creating the coronavirus disease 2019 …

Mutations on RBD of SARS-CoV-2 Omicron variant result in stronger binding to human ACE2 receptor

CS Lupala, Y Ye, H Chen, XD Su, H Liu - Biochemical and biophysical …, 2022 - Elsevier
The COVID-19 pandemic caused by the SARS-CoV-2 virus has led to more than 270 million
infections and 5.3 million of deaths worldwide. Several major variants of SARS-CoV-2 have …

Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants

M Yuan, D Huang, CCD Lee, NC Wu, AM Jackson… - Science, 2021 - science.org
Neutralizing antibodies (nAbs) elicited against the receptor binding site (RBS) of the spike
protein of wild-type severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are …