Epigallocatechin Gallate with Potent Anti-Helicobacter pylori Activity Binds Efficiently to Its Histone-like DNA Binding Protein

R Raj, N Agarwal, S Raghavan, T Chakraborti… - ACS …, 2021 - ACS Publications
Helicobacter pylori (H. pylori)—a human gastric pathogen—forms a major risk factor for the
development of various gastric pathologies such as chronic inflammatory gastritis, peptic …

Structure-based inhibitors targeting the alpha-helical domain of the Spiroplasma melliferum histone-like HU protein

YK Agapova, DA Altukhov, VI Timofeev, VS Stroylov… - Scientific Reports, 2020 - nature.com
Here we report bisphenol derivatives of fluorene (BDFs) as a new type of chemical probes
targeting a histone-like HU protein, a global regulator of bacterial nucleoids, via its …

Spectroscopic study of conformation changes of bovine serum albumin in aqueous environment

C Guo, X Guo, W Chu, N Jiang, H Li - Chinese Chemical Letters, 2019 - Elsevier
The secondary structural changes of bovine serum albumin (BSA) aqueous solutions with
and without calcium cations were investigated by attenuated total reflection-Fourier …

Exquisite binding interaction of 18β-Glycyrrhetinic acid with histone like DNA binding protein of Helicobacter pylori: A computational and experimental study

R Raj, N Agarwal, S Raghavan, T Chakraborti… - International Journal of …, 2020 - Elsevier
The Histone-like DNA binding protein is one of the most abundant nucleoid associated
protein expressed by human gastric-pathogen, Helicobacter pylori (H. pylori). The protein …

Molecular Insights into Conformational Heterogeneity and Enhanced Structural Integrity of Helicobacter pylori DNA Binding Protein Hup at Low pH

N Agarwal, N Jaiswal, K Gulati, K Gangele, N Nagar… - Biochemistry, 2021 - ACS Publications
The summarized amalgam of internal relaxation modulations and external forces like pH,
temperature, and solvent conditions determine the protein structure, stability, and function. In …

Dissecting the differential structural and dynamics features of CCL2 chemokine orthologs

N Joshi, N Nagar, K Gulati, K Gangele, A Mishra… - International journal of …, 2020 - Elsevier
Chemokines are a sub-group of cytokines that regulate the leukocyte migration. Monocyte
chemoattractant protein-1 (MCP/CCL2) is one of the essential CC chemokine that regulates …

Molecular interaction between human SUMO-I and histone like DNA binding protein of Helicobacter pylori (Hup) investigated by NMR and other biophysical tools

N Jaiswal, N Agarwal, A Kaur, S Tripathi… - International journal of …, 2019 - Elsevier
The proteins secreted by bacteria contribute to immune mediated gastric inflammation and
epithelial damage; thus aid bacterial invasion in host tissue, and may also interact with host …

Conserved Apical Proline Regulating the Structure and DNA Binding Properties of Helicobacter pylori Histone-like DNA Binding Protein (Hup)

N Agarwal, N Nagar, R Raj, D Kumar, KM Poluri - ACS omega, 2022 - ACS Publications
Prokaryotic cells lack a proper dedicated nuclear arrangement machinery. A set of proteins
known as nucleoid associated proteins (NAPs) perform opening and closure of nucleic …

Multimodal spectroscopic methods for the analysis of carbohydrates

N Sharma, H Pandey, AK Sonkar, M Gondwal… - … Methods to Study …, 2023 - Elsevier
Carbohydrates are the important biomolecules that occupy the central position in the
metabolism of biological systems. It is considered one of the essential nutrients and is the …

Significance of a histone-like protein with its native structure for the diagnosis of asymptomatic tuberculosis

Y Ohara, Y Ozeki, Y Tateishi, T Mashima, F Arisaka… - PloS one, 2018 - journals.plos.org
Tuberculosis causes the highest mortality among all single infections. Asymptomatic
tuberculosis, afflicting one third of the global human population, is the major source as 5 …