Allergic Diseases and Childhood Obesity: A Detrimental Link?

C Stefani, L Pecoraro, CE Flodmark, M Zaffanello… - Biomedicines, 2023 - mdpi.com
Several epidemiological studies have described childhood obesity as a risk factor for atopic
disease, particularly asthma. At the same time, this association seems to be more conflicting …

Impact of obesity in asthma: Possible future therapies

H Tashiro, Y Kurihara, Y Kuwahara… - Allergology …, 2024 - jstage.jst.go.jp
abstract Obesity is one of the factors associated with the severity of asthma. Obesity is
associated with aggravation of the pathophysiology of asthma, including exacerbations …

Characterization of obesity in severe asthma in the German Asthma Net

C Bal, W Pohl, K Milger, D Skowasch, C Schulz… - The Journal of Allergy …, 2023 - Elsevier
Background Asthma is increasingly recognized as heterogeneous, characterized by different
endotypes, with obesity not only a distinct phenotype but a risk factor for severe asthma …

Documentation of comorbidities, lifestyle factors, and asthma management during primary care scheduled asthma contacts

J Takala, I Vähätalo, LE Tuomisto, O Niemelä… - NPJ Primary Care …, 2024 - nature.com
Systematically assessing asthma during follow-up contacts is important to accomplish
comprehensive treatment. No previous long-term studies exist on how comorbidities …

[HTML][HTML] Revealing polygenic pleiotropy using genetic risk scores for asthma

M Dapas, YL Lee, W Wentworth-Sheilds, HK Im… - Human Genetics and …, 2023 - cell.com
In this study we examined how genetic risk for asthma associates with different features of
the disease and with other medical conditions and traits. Using summary statistics from two …

The impact of steroid-sparing biologic therapies on weight loss in obese individuals with severe eosinophilic asthma

AM Nanzer, V Taylor, AP Hearn… - European …, 2023 - Eur Respiratory Soc
Extract Asthma and obesity are prevalent disorders with significant impact on public health.
Obesity is a reported risk factor for the development of asthma and is associated with …

Asthma prevalence and phenotyping in the general population: the LEAD (lung, hEart, sociAl, boDy) study

C Schiffers, EFM Wouters… - Journal of Asthma …, 2023 - Taylor & Francis
Background Asthma is a chronic heterogeneous respiratory disease involving differential
pathophysiological pathways and consequently distinct asthma phenotypes. Objective and …

Why has epidemiology not (yet) succeeded in identifying the origin of the asthma epidemic?

JM Antó, N Pearce, J Douwes… - International Journal …, 2023 - academic.oup.com
In the 1980s many industrialized countries experienced large increases in the prevalence of
asthma with the term 'asthma epidemic'becoming popular. 1, 2 Since epidemiology had …

Exploring the association between asthma and chronic comorbidities: impact on clinical outcomes

AS Listyoko, R Okazaki, T Harada, G Inui… - Frontiers in …, 2024 - frontiersin.org
Asthma remains a significant global health challenge. While both the incidence and mortality
rates have shown a decline, older individuals with asthma exhibit not just more severe …

Mechanistic links between obesity and airway pathobiology inform therapies for obesity-related asthma

SC Guerrero, RA Panettieri Jr, D Rastogi - Pediatric Drugs, 2023 - Springer
Obesity-related asthma is associated with a high disease burden and a poor response to
existent asthma therapies, suggesting that it is a distinct asthma phenotype. The proposed …