The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes

P Capewell, C Cren-Travaillé, F Marchesi, P Johnston… - Elife, 2016 - elifesciences.org
The role of mammalian skin in harbouring and transmitting arthropod-borne protozoan
parasites has been overlooked for decades as these pathogens have been regarded …

Human host determinants influencing the outcome of Trypanosoma brucei gambiense infections

B Bucheton, A MacLeod, V Jamonneau - Parasite Immunology, 2011 - Wiley Online Library
Since first identified, human African trypanosomiasis (HAT) or sleeping sickness has been
described as invariably fatal. Increasing data however argue that infection by Trypanosoma …

[HTML][HTML] The elimination of Trypanosoma brucei gambiense? Challenges of reservoir hosts and transmission cycles: Expect the unexpected

D Mehlitz, DH Molyneux - Parasite Epidemiology and Control, 2019 - Elsevier
Abstract The World Health Organisation has set the goal for elimination of Human African
Trypanosomiasis (HAT), caused by Trypanosoma brucei gambiense (gHAT), as a public …

Untreated Human Infections by Trypanosoma brucei gambiense Are Not 100% Fatal

V Jamonneau, H Ilboudo, J Kaboré… - PLoS neglected …, 2012 - journals.plos.org
The final outcome of infection by Trypanosoma brucei gambiense, the main agent of
sleeping sickness, has always been considered as invariably fatal. While scarce and old …

APOL1 renal risk variants have contrasting resistance and susceptibility associations with African trypanosomiasis

A Cooper, H Ilboudo, VP Alibu, S Ravel, J Enyaru… - elife, 2017 - elifesciences.org
Reduced susceptibility to infectious disease can increase the frequency of otherwise
deleterious alleles. In populations of African ancestry, two apolipoprotein-L1 (APOL1) …

Estimates of the duration of the early and late stage of gambiense sleeping sickness

F Checchi, JAN Filipe, DT Haydon… - BMC infectious …, 2008 - Springer
Background The durations of untreated stage 1 (early stage, haemo-lymphatic) and stage 2
(late stage, meningo-encephalitic) human African trypanosomiasis (sleeping sickness) due …

The study of trypanosome species circulating in domestic animals in two human African trypanosomiasis foci of Cote d'Ivoire identifies pigs and cattle as potential …

MK N'Djetchi, H Ilboudo, M Koffi, J Kaboré… - PLoS neglected …, 2017 - journals.plos.org
Background Important control efforts have led to a significant reduction of the prevalence of
human African trypanosomiasis (HAT) in Côte d'Ivoire, but the disease is still present in …

Resolving the apparent transmission paradox of African sleeping sickness

P Capewell, K Atkins, W Weir, V Jamonneau… - PLOS …, 2019 - journals.plos.org
Human African trypanosomiasis (HAT), or African sleeping sickness, is a fatal disease found
throughout sub-Saharan Africa. The disease is close to elimination in many areas, although …

Human African trypanosomiasis presenting at least 29 years after infection—what can this teach us about the pathogenesis and control of this neglected tropical …

D Sudarshi, S Lawrence, WO Pickrell… - PLoS neglected …, 2014 - journals.plos.org
The World Health Organization (WHO) has recently announced its plan to eliminate Human
African trypanosomiasis (HAT). The plan's main focus is on the Trypanosoma brucei …

Prevalence of blood and skin trypanosomes in domestic and wild fauna from two sleeping sickness foci in Southern Cameroon

EMK Magang, RMN Kamga, J Telleria… - PLoS Neglected …, 2023 - journals.plos.org
Although studies on African Trypanosomiases revealed a variety of trypanosome species in
the blood of various animal taxa, animal reservoirs of Trypanosoma brucei gambiense and …