This review focuses on neuropeptides and peptide hormones, the largest and most diverse
class of neuroactive substances, known in Drosophila and other animals to play roles in …

Insulin, insulin-like growth factors (IGFs) and insulin-like peptides (ILPs) are important
regulators of metabolism, growth, reproduction and lifespan, and mechanisms of insulin/IGF …

Our highly seasonal world restricts insect activity to brief portions of the year. This feature
necessitates a sophisticated interpretation of seasonal changes and enactment of …

Mapping neural circuits across defined synapses is essential for understanding brain
function. Here we describe trans-Tango, a technique for anterograde transsynaptic circuit …

We generated a library of~ 1000 Drosophila stocks in which we inserted a construct in the
intron of genes allowing expression of GAL4 under control of endogenous promoters while …

The enteroendocrine cell (EEC)-derived incretins play a pivotal role in regulating the
secretion of glucagon and insulins in mammals. Although glucagon-like and insulin-like …

The efficacy of neuronal function requires a well-balanced extracellular ion homeostasis and
a steady supply with nutrients and metabolites. Therefore, all organisms equipped with a …

Taking advantage of Drosophila as a genetically tractable experimental animal much
progress has been made in our understanding of how the insulin/IGF signaling (IIS) pathway …

Winter provides many challenges for insects, including direct injury to tissues and energy
drain due to low food availability. As a result, the geographic distribution of many species is …

Hormones regulate development, as well as many vital processes in the daily life of an
animal. Many of these hormones are peptides that act at a higher hierarchical level in the …