With rapid advances in sequencing technologies, tremendous progress has been made in
understanding the molecular pathogenesis of acute myeloid leukaemia (AML), thus …

Abstract Nucleophosmin 1 (NPM1) is a nucleus-cytoplasmic shuttling protein which is
predominantly located in the nucleolus and exerts multiple functions, including regulation of …

MicroRNAs (miRNAs or miRs) are a class of evolutionarily-conserved small, regulatory non-
coding RNAs, 19–3 nucleotides in length, that negatively regulate protein coding gene …

The homeobox (HOX) genes encoding an evolutionarily highly conserved family of
homeodomain-containing transcriptional factors are essential for embryogenesis and …

Homeobox (HOX) transcription factors, encoded by a subset of homeodomain superfamily
genes, play pivotal roles in many aspects of cellular physiology, embryonic development …

Gastric cancer (GC) was the fourth deadliest cancer in the world in 2020, and about 770,000
people died from GC that year. The death of patients with GC is mainly caused by the …

Alzheimer's disease (AD) is the most common cause of dementia and cannot be cured. The
etiology and pathogenesis of AD is still not fully understood, the genetics is considered to be …

Leukaemia stem cells (LSCs) in acute myeloid leukaemia present a considerable treatment
challenge due to their resistance to chemotherapy and immunosurveillance. The connection …

Leukemia is caused by the accumulation of multiple genomic lesions in hematopoietic
precursor cells. However, how these events cooperate during oncogenic transformation …

Spleen tyrosine kinase (SYK) plays a critical role in immune cell signaling pathways and has
been reported as a biomarker for human hepatocellular carcinoma (HCC). We sought to …