Chronic diseases that affect our society are made more complex by comorbidities and are
poorly managed by the current pharmacology. While all present inflammatory …

Annexins are cytosolic proteins with conserved three-dimensional structures that bind acidic
phospholipids in cellular membranes at elevated Ca2+ levels. Through this they act as Ca2+ …

Annexin-A1 (ANXA1) has recently been proposed to play a role in microglial activation after
brain ischemia, but the underlying mechanism remains poorly understood. Here, we …

Short-chain fatty acids (SCFAs) are metabolites produced mainly by the gut microbiota with
a known role in immune regulation. Acetate, the major SCFA, is described to disseminate to …

A complex intracellular signaling governs different cellular responses in inflammation.
Extracellular stimuli are sensed, amplified, and transduced through a dynamic cellular …

Formyl peptide receptors (FPRs) belong to the G protein-coupled receptor (GPCR) family
and are well known as chemotactic receptors and pattern recognition receptors (PRRs) that …

Routine manipulation of the mouse genome has become a landmark in biomedical
research. Traits that are only associated with advanced developmental stages can now be …

Nonphlogistic migration of macrophages contributes to the clearance of pathogens and
apoptotic cells, a critical step for the resolution of inflammation and return to homeostasis …

COVID‐19, the illness caused by SARS‐CoV‐2, has a wide‐ranging clinical spectrum that,
in the worst‐case scenario, involves a rapid progression to severe acute respiratory …

Dysregulated inflammatory responses are often correlated with disease severity during viral
infections. Annexin A1 (AnxA1) is an endogenous pro-resolving protein that timely regulates …