Cochlear inflammaging in relation to ion channels and mitochondrial functions

P Bazard, J Pineros, RD Frisina, MA Bauer, AA Acosta… - Cells, 2021 - mdpi.com
The slow accumulation of inflammatory biomarker levels in the body—also known as
inflammaging—has been linked to a myriad of age-related diseases. Some of these include …

Roles of key ion channels and transport proteins in age-related hearing loss

P Bazard, RD Frisina, AA Acosta, S Dasgupta… - International Journal of …, 2021 - mdpi.com
The auditory system is a fascinating sensory organ that overall, converts sound signals to
electrical signals of the nervous system. Initially, sound energy is converted to mechanical …

Licorice metabolite 18β‐glycyrrhetinic acid activates G protein‐gated inwardly rectifying K+ channels

IS Chen, J Yasuda, T Notomi… - British Journal of …, 2024 - Wiley Online Library
Background and Purpose Licorice (liquorice) is a common food additive and is used in
Chinese medicine. Excess licorice intake can induce atrial fibrillation. Patients with atrial …

[HTML][HTML] Acceleration of GABA-switch after early life stress changes mouse prefrontal glutamatergic transmission

H Karst, WJ Droogers, N van der Weerd… - …, 2023 - Elsevier
Early life stress (ELS) alters the excitation-inhibition-balance (EI-balance) in various rodent
brain areas and may be responsible for behavioral impairment later in life. The EI-balance is …

Dietary Na+ depletion up-regulates NKCC1 expression and enhances electrogenic Cl secretion in rat proximal colon

AJ Nickerson, VM Rajendran - Cellular and Molecular Life Sciences, 2023 - Springer
The corticosteroid hormone, aldosterone, markedly enhances K+ secretion throughout the
colon, a mechanism critical to its role in maintaining overall K+ balance. Previous studies …

Post-translational modifications and age-related hearing loss

P Bazard, J Pineros, AA Acosta, M Thivierge… - Hearing Research, 2022 - Elsevier
Post-translational modifications (PTMs) affect nearly all systems of the human body due to
their role in protein synthesis and functionality. These reversible and irreversible …

Conditional ablation of glucocorticoid and mineralocorticoid receptors from cochlear supporting cells reveals their differential roles for hearing sensitivity and dynamics …

CC Barnes, KT Yee, DE Vetter - International Journal of Molecular …, 2023 - mdpi.com
Endogenous glucocorticoids (GC) are known to modulate basic elements of cochlear
physiology. These include both noise-induced injury and circadian rhythms. While GC …

L-Ergothioneine slows the progression of age-related hearing loss in CBA/CaJ mice

MA Bauer, P Bazard, AA Acosta, N Bangalore… - Hearing Research, 2024 - Elsevier
The naturally occurring amino acid, l-ergothioneine (EGT), has immense potential as a
therapeutic, having shown promise in the treatment of other disease models, including …

Connexins 30 and 43 expression changes in relation to age-related hearing loss

J Pineros, X Zhu, B Ding, RD Frisina - Hearing Research, 2024 - Elsevier
Age-related hearing loss (ARHL), also known as presbycusis, is the number one
communication disorder for aging adults. Connexin proteins are essential for intercellular …

The Roles of Solute Carriers in Auditory Function

F Qian, X Jiang, R Chai, D Liu - Frontiers in Genetics, 2022 - frontiersin.org
Solute carriers (SLCs) are important transmembrane transporters with members organized
into 65 families. They play crucial roles in transporting many important molecules, such as …