Site-predictable and chemoselective C–H bond functionalization reactions offer synthetically
powerful strategies for the step-economic diversification of both feedstock and fine …

1, 1, 1, 3, 3, 3-Hexafluoroisopropanol (HFIP) is a polar, strongly hydrogen bond-donating
solvent that has found numerous uses in organic synthesis due to its ability to stabilize ionic …

During the past decades, synthetic organic chemistry discovered that directing group
assisted C–H activation is a key tool for the expedient and siteselective construction of C–C …

Peptides are a growing therapeutic class due to their unique spatial characteristics that can
target traditionally “undruggable” protein–protein interactions and surfaces. Despite their …

Despite the great strides in healthcare during the last century, some challenges still
remained unanswered. The development of multi-drug resistant bacteria, the alarming …

Antibiotic resistance is one of the greatest challenges of our time. This global health problem
originated from a paucity of truly effective antibiotic classes and an increased incidence of …

The growing importance of peptides and proteins in therapeutic and biomedical applications
has provided immense motivation toward the development of new ways to construct and …

Bioorthogonal late-stage diversification of amino acids and peptides bears enormous
potential for drug discovery and molecular imaging. Despite major accomplishments, these …

The central dogma of modern biology underscores the pivotal roles proteins play in diverse
biological processes, the study of which necessitates advanced methods to produce …

Peptide macrocyclization has traditionally relied on lactam, lactone and disulfide bond-
forming reactions that aim at introducing conformational constraints into small peptide …