The levels of p53 govern the hierarchy of DNA damage tolerance pathway usage
BA Castaño, S Schorer, Y Guo, NL Calzetta… - Nucleic Acids …, 2024 - academic.oup.com
It is well-established that, through canonical functions in transcription and DNA repair, the
tumor suppressor p53 plays a central role in safeguarding cells from the consequences of …
tumor suppressor p53 plays a central role in safeguarding cells from the consequences of …
SEOM clinical guideline on heritable TP53-related cancer syndrome (2022)
AB Sánchez-Heras, T Ramon y Cajal, M Pineda… - Clinical and …, 2023 - Springer
Li-Fraumeni syndrome is caused by heterozygous germline pathogenic variants in the TP53
gene. It involves a high risk of a variety of malignant tumors in childhood and adulthood, the …
gene. It involves a high risk of a variety of malignant tumors in childhood and adulthood, the …
[HTML][HTML] Genetic modifiers of p53: opportunities for breast cancer therapies
Each day our cells encounter a wide range of genomic damage and the p53 protein
arbitrates decisions of cell cycle arrest to allow repair of DNA or promote elimination of cells …
arbitrates decisions of cell cycle arrest to allow repair of DNA or promote elimination of cells …
Impact of Simulated Rotating Shift Work on Mammary Tumor Development in the p53R270H©/+WAPCre Mouse Model for Breast Cancer
AA Streng, KCG Van Dycke… - Journal of …, 2023 - journals.sagepub.com
Epidemiological studies associate night shift work with increased breast cancer risk.
However, the underlying mechanisms are not clearly understood. To better understand …
However, the underlying mechanisms are not clearly understood. To better understand …
The BA-BCS 2021: an initial “trial” for integrating basic science and medical progress on breast cancer in a Latin-American country
Abstract The first Buenos Aires Breast Cancer Symposium (BA-BCS) was held in a virtual
format, between the 17 th and the 21 st of May 2021. The main goal of the meeting was to …
format, between the 17 th and the 21 st of May 2021. The main goal of the meeting was to …
[PDF][PDF] Variation in DNA Repair Mechanisms Can Influence Effects of Oestrogen and Environmental Chemicals on Breast Cancer Susceptibility
DJ Jerry - scientia.global
At some point in their lifetime, 1 in 8 women in the USA will be diagnosed with breast cancer.
Genetic factors and exposure to endogenous (ie, internal) and environmental hormones can …
Genetic factors and exposure to endogenous (ie, internal) and environmental hormones can …