The hepatocyte nuclear factors (HNFs) namely HNF1α/β, FOXA1/2/3, HNF4α/γ and
ONECUT1/2 are expressed in a variety of tissues and organs, including the liver, pancreas …

Adult hepatocyte identity is constructed throughout embryonic development and fine-tuned
after birth. A multinodular network of transcription factors, along with pre-mRNA splicing …

Discoveries concerning the molecular mechanisms of cell differentiation and development
have dictated the definition of a new sub-discipline of genetics known as epigenetics …

Generation of hepatocytes from human embryonic stem cells (hESCs) could represent an
advantageous source of cells for cell therapy approaches as an alternative to orthotopic liver …

Wnt signalling, which is transduced through β-catenin/TCF4, maintains the undifferentiated
state of intestinal crypt progenitor cells,. Mutational activation of the pathway initiates the …

Transcriptional Activation. The liver performs essential functions in the body by uniquely
expressing hepatocyte-specific genes encoding plasma proteins, clotting factors and …

Hepatocyte nuclear factor 4-alpha (HNF4-α) is a nuclear receptor regulating metabolism,
cell junctions, differentiation and proliferation in liver and intestinal epithelial cells. Mutations …

Cross-regulatory cascades between hepatic transcription factors have been implicated in
the determination of the hepatic phenotype. Analysis of recruitments to regulatory regions …

In recent years, human mesenchymal stem cells (MSC) have been extensively studied. Their
key characteristics of long-term self-renewal and a capacity to differentiate into diverse …

The liver produces plasma sex hormone–binding globulin (SHBG), which transports sex
steroids and regulates their access to tissues. In overweight children and adults, low plasma …