The Mediator complex, which in humans is 1.4 MDa in size and includes 26 subunits,
controls many aspects of RNA polymerase II (Pol II) function. Apart from its size, a defining …

De novo mutations in protein-coding genes are a well-established cause of developmental
disorders. However, genes known to be associated with developmental disorders account …

Abstract Cyclin-dependent kinase 8 (CDK8) plays an momentous role in transcription
regulation by forming kinase module or transcription factor phosphorylation. A large number …

To select candidate genes for goat prolificacy, we managed six multi-and six single-kid
female goats at the same feeding level and in the same management mode over a 4-year …

We identified three unrelated individuals with de novo missense variants in CDK19,
encoding a cyclin-dependent kinase protein family member that predominantly regulates …

Neurological diseases, including traumatic brain injuries, stroke (haemorrhagic and
ischemic), and inherent neurodegenerative diseases cause acquired disability in humans …

Extensive studies in the past 30 years have established that cyclin-dependent kinases
(CDKs) exert many diverse, important functions in a number of molecular and cellular …

The developmentally indispensable Notch pathway exhibits a high grade of pleiotropism in
its biological output. Emerging evidence supports the notion of post-translational …

De novo mutations (DNMs) in protein-coding genes are a well-established cause of
developmental disorders (DD). However, known DD-associated genes only account for a …

The Mediator complex is an essential coregulator of RNA polymerase II transcription. More
recent developments suggest Mediator functions as a link between transcription regulation …