Current situation of leprosy in India and its future implications

PN Rao, S Suneetha - Indian dermatology online journal, 2018 - journals.lww.com
The global leprosy situation has changed significantly over the last four decades after the
introduction of multidrug therapy (MDT) in 1982 with a reduction in prevalence from over 5 …

Natural-product-based solutions for tropical infectious diseases

O Adegboye, MA Field, A Kupz, S Pai… - Clinical microbiology …, 2021 - Am Soc Microbiol
About half of the world's population and 80% of the world's biodiversity can be found in the
tropics. Many diseases are specific to the tropics, with at least 41 diseases caused by …

Putting Crohn's on the MAP: Five Common Questions on the Contribution of Mycobacterium avium subspecies paratuberculosis to the Pathophysiology of Crohn's …

G Agrawal, J Aitken, H Hamblin, M Collins… - Digestive Diseases and …, 2021 - Springer
For decades, Mycobacterium avium subspecies paratuberculosis (MAP) has been linked to
the pathogenesis of Crohn's disease. Despite many investigations and research efforts …

Treatment of leprosy

HK Kar, R Gupta - Clinics in dermatology, 2015 - Elsevier
Leprosy is a curable disease, having been eliminated from many countries, including India.
This has been possible due to the wide availability of effective and safe drugs. Treatment of …

Intracellular Mycobacterium leprae utilizes host glucose as a carbon source in Schwann cells

K Borah, KCV Girardi, TA Mendum, LMS Lery… - MBio, 2019 - Am Soc Microbiol
New approaches are needed to control leprosy, but understanding of the biology of the
causative agent Mycobacterium leprae remains rudimentary, principally because the …

Caregivers' views on stigmatization and discrimination of people affected by leprosy in Ghana

E Asampong, M Dako–Gyeke… - PLoS neglected tropical …, 2018 - journals.plos.org
Background Leprosy is a condition that has long been associated with stigma and
discrimination, even when infected persons have been cured. This paper describes stigma …

Interaction of constituents of MDT regimen for leprosy with Mycobacterium leprae HSP18: impact on its structure and function

A Chakraborty, R Ghosh, A Biswas - The FEBS Journal, 2022 - Wiley Online Library
Mycobacterium leprae, the causative organism of leprosy, harbors many antigenic proteins,
and one such protein is the 18‐kDa antigen. This protein belongs to the small heat shock …

Combination chemoprophylaxis and immunoprophylaxis in reducing the incidence of leprosy

MS Duthie, MF Balagon - Risk management and healthcare policy, 2016 - Taylor & Francis
Leprosy is a complex infectious disease caused by Mycobacterium leprae that is a leading
cause of nontraumatic peripheral neuropathy. Current control strategies, with a goal of early …

[HTML][HTML] Efficacy of fixed duration multidrug therapy for the treatment of multibacillary leprosy: A prospective observational study from Northern India

I Singh, M Ahuja, M Lavania, VK Pathak… - Indian Journal of …, 2023 - ijdvl.com
Background: In endemic regions of several countries, the prevalence of leprosy has not
come down to the level of elimination. On the contrary, new cases are being detected in …

Nitazoxanide is active against Mycobacterium leprae

MA Bailey, H Na, MS Duthie, TP Gillis, R Lahiri… - PLoS …, 2017 - journals.plos.org
Nitazoxanide (NTZ) is an anti-parasitic drug that also has activity against bacteria, including
Mycobacterium tuberculosis. Our data using both radiorespirometry and live-dead staining …