Advanced methods for natural products discovery: bioactivity screening, dereplication, metabolomics profiling, genomic sequencing, databases and informatic tools …

SP Gaudêncio, E Bayram, L Lukić Bilela, M Cueto… - Marine drugs, 2023 - mdpi.com
Natural Products (NP) are essential for the discovery of novel drugs and products for
numerous biotechnological applications. The NP discovery process is expensive and time …

Computational chemistry to the rescue: Modern toolboxes for the assignment of complex molecules by GIAO NMR calculations

N Grimblat, AM Sarotti - Chemistry–A European Journal, 2016 - Wiley Online Library
The calculations of NMR properties of molecules using quantum chemical methods have
deeply impacted several branches of organic chemistry. They are particularly important in …

Pyrrolizidine alkaloids: occurrence, biology, and chemical synthesis

J Robertson, K Stevens - Natural Product Reports, 2017 - pubs.rsc.org
Covering: 2013 up to the end of 2015 This review covers the isolation and structure of new
pyrrolizidines; pyrrolizidine biosynthesis; biological activity, including the occurrence of …

Structural characterisation of natural products by means of quantum chemical calculations of NMR parameters: New insights

FLP Costa, ACF de Albuquerque, RG Fiorot… - Organic Chemistry …, 2021 - pubs.rsc.org
In the early 2000s, the first articles regarding the calculation of NMR parameters for natural
products appeared in the literature. Since then, modelling 1H and 13C chemical shifts and …

Pyrrolizidine alkaloids

J Tamariz, E Burgueño-Tapia, MA Vázquez… - The alkaloids: chemistry …, 2018 - Elsevier
Naturally occurring pyrrolizidine alkaloids (PAs) are isolated from plants and other sources.
The interest of the scientific community in these compounds owes itself to their high toxicity …

Are we still chasing molecules that were never there? The role of quantum chemical simulations of NMR parameters in structural reassignment of natural products

ACF de Albuquerque, LH Martorano… - Frontiers in Natural …, 2024 - frontiersin.org
Covering: 2019 to 2023. Even with the advent of modern and complementary spectroscopy
techniques, comprehensive characterization of natural product continues to represent an …

Pyrrolizidine Alkaloids: The Botanical Origin of Pollen Collected during the Flowering Period of Echium vulgare and the Stability of Pyrrolizidine Alkaloids in Bee …

C Kast, V Kilchenmann, H Reinhard, K Bieri, O Zoller - Molecules, 2019 - mdpi.com
Previous studies have shown that pollen products sold as nutritional supplements and used
in apitherapy may contain toxic pyrrolizidine alkaloids (PAs) if bees collect pollen from PA …

Chemical fingerprinting identifies Echium vulgare, Eupatorium cannabinum and Senecio spp. as plant species mainly responsible for pyrrolizidine alkaloids in bee …

C Kast, V Kilchenmann, H Reinhard… - Food Additives & …, 2018 - Taylor & Francis
Various studies have shown that bee-collected pollen sold as nutritional supplements may
contain toxic pyrrolizidine alkaloids (PAs) and, thus, pose a potential health risk for …

Isovincathicine from Catharanthus roseus induces apoptosis in A549 cells

M Hiroki, A Abulikemu, C Totsuka, Y Hirasawa… - Journal of Natural …, 2024 - Springer
A dimeric indole alkaloid, isovincathicine consisting of an aspidosperma type and modified
iboga with C-7–C-20 connection type skeletons was first isolated from Catharanthus roseus …

Vincazalidine A, a unique bisindole alkaloid from Catharanthus roseus

Y Hirasawa, A Kase, A Okamoto, K Suzuki… - Journal of Natural …, 2024 - Springer
A new dimeric indole alkaloid, vincazalidine A consisting of an aspidosperma type and a
modified iboga type with 1-azatricyclo ring system consisting of one azepane and two …