Since the initial development of the exposome concept, much effort has been devoted to the
characterisation of the exposome through analytical, epidemiological, and toxicological …

The gut-liver axis covers the bidirectional communication between the gut and the liver, and
thus includes signals from liver-to-gut (eg, bile acids, immunoglobulins) and from gut-to-liver …

Although disrupted bile acid (BA) homeostasis is implicated in inflammatory bowel disease
(IBD), the role of hepatic BA metabolism in the pathogenesis of colitis is poorly understood …

As an effective drug against acute enteritis diarrhea, Gegen Qinlian decoction (GQD) has a
history of 2000 years. However, the potential molecular mechanism through which GQD …

Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown
aetiology for which there are no approved therapeutic options. Patients with PSC display …

Chronic liver disease (CLD) is one of the leading causes of disability-adjusted life years in
many countries. A recent understanding of nuclear bile acid receptor pathways has …

The gut-liver axis describes the physiological interplay between the gut and the liver and
has important implications for the maintenance of health. Disruptions of this equilibrium are …

As an organ critically important for targeting and clearing viruses, bacteria, and other foreign
material, the liver operates via immune-tolerant, anti-inflammatory mechanisms …

Bile acids are important hydroxylated steroids that are synthesized in the liver from
cholesterol for intestinal absorption of lipids and other fatty-nutrient. They also display …

Background: Primary sclerosing cholangitis (PSC) is frequently associated with pruritus,
which significantly impairs quality of life. Maralixibat is a selective ileal bile acid transporter …