Effects of SARS-CoV-2 Main Protease Mutations at Positions L50, E166, and L167 Rendering Resistance to Covalent and Noncovalent Inhibitors
A Kovalevsky, A Aniana, R Ghirlando… - Journal of Medicinal …, 2024 - ACS Publications
SARS-CoV-2 propagation under nirmatrelvir and ensitrelvir pressure selects for main
protease (MPro) drug-resistant mutations E166V (DRM2), L50F/E166V (DRM3) …
protease (MPro) drug-resistant mutations E166V (DRM2), L50F/E166V (DRM3) …
Nirmatrelvir: From Discovery to Modern and Alternative Synthetic Approaches
M Galli, F Migliano, V Fasano, A Silvani, D Passarella… - Processes, 2024 - mdpi.com
áThe global urgency in response to the COVID-19 pandemic has catalyzed extensive
research into discovering efficacious antiviral compounds against SARS-CoV-2. Among …
research into discovering efficacious antiviral compounds against SARS-CoV-2. Among …
Exploration of N3H site in nirmatrelvir: Design, synthesis, evaluation, and DFT studies of solvates and cocrystals
G Li, B Jiang, Y Huang, J Shi, H Pan, H Shan… - Journal of Molecular …, 2025 - Elsevier
This study successfully obtained three new crystal forms of nirmatrelvir targeting its N3H site:
the nirmatrelvir isobutyl acetate solvate (Solvate II), cocrystals with triethylene diamine …
the nirmatrelvir isobutyl acetate solvate (Solvate II), cocrystals with triethylene diamine …
[PDF][PDF] Nirmatrelvir: From Discovery to Modern and Alternative Synthetic Approaches. Processes 2024, 12, 1242. htps
M Galli, F Migliano, V Fasano, A Silvani… - doi. org/10.3390 …, 2024 - researchgate.net
The global urgency in response to the COVID-19 pandemic has catalyzed extensive
research into discovering efficacious antiviral compounds against SARS-CoV-2. Among …
research into discovering efficacious antiviral compounds against SARS-CoV-2. Among …
[PDF][PDF] Synthesis and SAR Studies of Coronavirus Main Protease Inhibitors
P Bailey - 2024 - digital.wpi.edu
SARS-CoV-2 has been extremely impactful the last few years, with more than 774 million
confirmed cases and more than 7 million deaths worldwide since the beginning of the …
confirmed cases and more than 7 million deaths worldwide since the beginning of the …
Exploration of N3h Modifications of Nirmatrelvir: Design, Synthesis, Evaluation, and Dft Studies of Nirmatrelvir Cocrystal
G Li, B Jiang, Y Huang, J Shi, H Pan, H Shan… - … , Evaluation, and Dft … - papers.ssrn.com
Nirmatrelvir belongs to a class of drugs capable of targeting all current COVID-19 variants,
demonstrating promising application in the field of anti-COVID-19 variants therapy. This …
demonstrating promising application in the field of anti-COVID-19 variants therapy. This …