Functional classification and experimental dissection of long noncoding RNAs

F Kopp, JT Mendell - Cell, 2018 - cell.com
Over the last decade, it has been increasingly demonstrated that the genomes of many
species are pervasively transcribed, resulting in the production of numerous long noncoding …

The emerging role of lncRNAs in cancer

M Huarte - Nature medicine, 2015 - nature.com
It is increasingly evident that many of the genomic mutations in cancer reside inside regions
that do not encode proteins. However, these regions are often transcribed into long …

[HTML][HTML] Identifying and characterizing circRNA-protein interaction

WW Du, C Zhang, W Yang, T Yong, FM Awan… - Theranostics, 2017 - ncbi.nlm.nih.gov
Circular RNAs have been identified as naturally occurring RNAs that are highly represented
in the eukaryotic transcriptome. Although a large number of circRNAs have been reported …

A census of human RNA-binding proteins

S Gerstberger, M Hafner, T Tuschl - Nature Reviews Genetics, 2014 - nature.com
Post-transcriptional gene regulation (PTGR) concerns processes involved in the maturation,
transport, stability and translation of coding and non-coding RNAs. RNA-binding proteins …

The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3

CA McHugh, CK Chen, A Chow, CF Surka, C Tran… - Nature, 2015 - nature.com
Many long non-coding RNAs (lncRNAs) affect gene expression, but the mechanisms by
which they act are still largely unknown. One of the best-studied lncRNAs is Xist, which is …

Revealing protein–lncRNA interaction

F Ferre, A Colantoni… - Briefings in …, 2016 - academic.oup.com
Long non-coding RNAs (lncRNAs) are associated to a plethora of cellular functions, most of
which require the interaction with one or more RNA-binding proteins (RBPs); similarly, RBPs …

Human long noncoding RNA interactome: detection, characterization and function

M Kazimierczyk, MK Kasprowicz, ME Kasprzyk… - International journal of …, 2020 - mdpi.com
The application of a new generation of sequencing techniques has revealed that most of the
genome has already been transcribed. However, only a small part of the genome codes …

Specificity and nonspecificity in RNA–protein interactions

E Jankowsky, ME Harris - Nature reviews Molecular cell biology, 2015 - nature.com
To fully understand the regulation of gene expression, it is critical to quantitatively define
whether and how RNA-binding proteins (RBPs) discriminate between alternative binding …

Long noncoding RNAs: an emerging link between gene regulation and nuclear organization

S Quinodoz, M Guttman - Trends in cell biology, 2014 - cell.com
Mammalian genomes encode thousands of long noncoding RNAs (lncRNAs) that play
important roles in diverse biological processes. As a class, lncRNAs are generally enriched …

HaloTag technology: a versatile platform for biomedical applications

CG England, H Luo, W Cai - Bioconjugate chemistry, 2015 - ACS Publications
Exploration of protein function and interaction is critical for discovering links among
genomics, proteomics, and disease state; yet, the immense complexity of proteomics found …