3′-untranslated regions (3′-UTRs) are the noncoding parts of mRNAs. Compared to
yeast, in humans, median 3′-UTR length has expanded approximately tenfold alongside …

RNA-binding proteins (RBPs) regulate essentially every event in the lifetime of an RNA
molecule, from its production to its destruction. Whereas much has been learned about RNA …

Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …

RNA-protein complexes play pivotal roles in many central biological processes. Although
methods based on high-throughput sequencing have advanced our ability to identify the …

The localization of RNAs critically contributes to many important cellular processes in an
organism, such as the establishment of polarity, asymmetric division and migration during …

Intracellular targeting of mRNAs has long been recognized as a means to produce proteins
locally, but has only recently emerged as a prevalent mechanism used by a wide variety of …

RNA aptamers can be expressed in cells to influence and image cellular processes.
Aptamer folding is maintained by inserting the aptamers into highly structured RNA …

Growing evidence indicates that translational control of specific mRNAs contributes
importantly to genetic regulation across the breadth of cellular and developmental …

Long-distance transport of mRNAs is important in determining polarity in eukaryotes.
Molecular motors shuttle large ribonucleoprotein complexes (mRNPs) containing RNA …

RNA binding proteins (RBPs) are key players in the regulation of gene expression. In this
chapter we discuss the main protein–RNA recognition modes used by RBPs in order to …