The emergence and influence of internal states

SW Flavell, N Gogolla, M Lovett-Barron, M Zelikowsky - Neuron, 2022 - cell.com
Animal behavior is shaped by a variety of" internal states"—partially hidden variables that
profoundly shape perception, cognition, and action. The neural basis of internal states, such …

Connectomics and the neural basis of behaviour

DS Galili, GSXE Jefferis, M Costa - Current opinion in insect science, 2022 - Elsevier
Highlights•Technical advances are producing bigger and denser Drosophila melanogaster
connectomes.•Mapping connectomics to other data types is a challenging but crucial …

[HTML][HTML] A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection

BK Hulse, H Haberkern, R Franconville… - Elife, 2021 - elifesciences.org
Flexible behaviors over long timescales are thought to engage recurrent neural networks in
deep brain regions, which are experimentally challenging to study. In insects, recurrent …

[HTML][HTML] Neuronal wiring diagram of an adult brain

S Dorkenwald, A Matsliah, AR Sterling, P Schlegel… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Connections between neurons can be mapped by acquiring and analyzing electron
microscopic (EM) brain images. In recent years, this approach has been applied to chunks of …

Sexual arousal gates visual processing during Drosophila courtship

T Hindmarsh Sten, R Li, A Otopalik, V Ruta - Nature, 2021 - nature.com
Long-lasting internal arousal states motivate and pattern ongoing behaviour, enabling the
temporary emergence of innate behavioural programs that serve the needs of an animal …

Make war not love: The neural substrate underlying a state-dependent switch in female social behavior

M Liu, DW Kim, H Zeng, DJ Anderson - Neuron, 2022 - cell.com
Female mice exhibit opposing social behaviors toward males depending on their
reproductive state: virgins display sexual receptivity (lordosis behavior), while lactating …

Flexible neural control of transition points within the egg-laying behavioral sequence in Drosophila

KM Cury, R Axel - Nature Neuroscience, 2023 - nature.com
Innate behaviors are frequently comprised of ordered sequences of component actions that
progress to satisfy essential drives. Progression is governed by specialized sensory cues …

[HTML][HTML] Driver lines for studying associative learning in Drosophila

Y Shuai, M Sammons, G Sterne, K Hibbard, H Yang… - eLife, 2024 - elifesciences.org
The mushroom body (MB) is the center for associative learning in insects. In Drosophila,
intersectional split-GAL4 drivers and electron microscopy (EM) connectomes have laid the …

Transforming a head direction signal into a goal-oriented steering command

EA Westeinde, E Kellogg, PM Dawson, J Lu… - Nature, 2024 - nature.com
To navigate, we must continuously estimate the direction we are headed in, and we must
correct deviations from our goal. Direction estimation is accomplished by ring attractor …

Connectome-constrained deep mechanistic networks predict neural responses across the fly visual system at single-neuron resolution

JK Lappalainen, FD Tschopp, S Prakhya, M McGill… - bioRxiv, 2023 - biorxiv.org
We can now measure the connectivity of every neuron in a neural circuit, but we are still
blind to other biological details, including the dynamical characteristics of each neuron. The …