Importin α: functions as a nuclear transport factor and beyond

M Oka, Y Yoneda - Proceedings of the Japan Academy, Series B, 2018 - jstage.jst.go.jp
Nucleocytoplasmic transport is an essential process in eukaryotes. The molecular
mechanisms underlying nuclear transport that involve the nuclear transport receptor, small …

Nuclear pore complex: biochemistry and biophysics of nucleocytoplasmic transport in health and disease

T Jamali, Y Jamali, M Mehrbod, MRK Mofrad - International review of cell …, 2011 - Elsevier
Nuclear pore complexes (NPCs) are the gateways connecting the nucleoplasm and
cytoplasm. This structures are composed of over 30 different proteins and 60–125 MDa of …

Germline genetic contribution to the immune landscape of cancer

RW Sayaman, M Saad, V Thorsson, D Hu, W Hendrickx… - Immunity, 2021 - cell.com
Understanding the contribution of the host's genetic background to cancer immunity may
lead to improved stratification for immunotherapy and to the identification of novel …

Landscape of nuclear transport receptor cargo specificity

MT Mackmull, B Klaus, I Heinze… - Molecular systems …, 2017 - embopress.org
Nuclear transport receptors (NTR s) recognize localization signals of cargos to facilitate their
passage across the central channel of nuclear pore complexes (NPC s). About 30 different …

Defects in nuclear pore assembly lead to activation of an Aurora B–mediated abscission checkpoint

DR Mackay, M Makise, KS Ullman - Journal of cell biology, 2010 - rupress.org
Correct assembly of nuclear pore complexes (NPCs), which directly and indirectly control
nuclear environment and architecture, is vital to genomic regulation. We previously found …

Nup50 is required for cell differentiation and exhibits transcription-dependent dynamics

AL Buchwalter, Y Liang, MW Hetzer - Molecular biology of the cell, 2014 - Am Soc Cell Biol
The nuclear pore complex (NPC) plays a critical role in gene expression by mediating import
of transcription regulators into the nucleus and export of RNA transcripts to the cytoplasm …

The Nup153-Nup50 protein interface and its role in nuclear import

M Makise, DR Mackay, S Elgort, SS Shankaran… - Journal of Biological …, 2012 - ASBMB
Interactions between Nup50 and soluble transport factors underlie the efficiency of certain
nucleocytoplasmic transport pathways. The platform on which these interactions take place …

The nucleoporin Nup50 activates the Ran guanine nucleotide exchange factor RCC1 to promote NPC assembly at the end of mitosis

G Holzer, P De Magistris, C Gramminger… - The EMBO …, 2021 - embopress.org
During mitotic exit, thousands of nuclear pore complexes (NPCs) assemble concomitant with
the nuclear envelope to build a transport‐competent nucleus. Here, we show that Nup50 …

Retinoblastoma-binding protein 4-regulated classical nuclear transport is involved in cellular senescence

A Tsujii, Y Miyamoto, T Moriyama, Y Tsuchiya… - Journal of Biological …, 2015 - ASBMB
Nucleocytoplasmic trafficking is a fundamental cellular process in eukaryotic cells. Here, we
demonstrated that retinoblastoma-binding protein 4 (RBBP4) functions as a novel regulatory …

A role for Nup153 in nuclear assembly reveals differential requirements for targeting of nuclear envelope constituents

D LaJoie, AM Turkmen, DR Mackay… - Molecular Biology of …, 2022 - Am Soc Cell Biol
Assembly of the nucleus following mitosis requires rapid and coordinate recruitment of
diverse constituents to the inner nuclear membrane. We have identified an unexpected role …