Endoplasmic reticulum stress: a critical molecular driver of endothelial dysfunction and cardiovascular disturbances associated with diabetes

H Maamoun, SS Abdelsalam, A Zeidan… - International journal of …, 2019 - mdpi.com
Physical inactivity and sedentary lifestyle contribute to the widespread epidemic of obesity
among both adults and children leading to rising cases of diabetes. Cardiovascular disease …

Endoplasmic reticulum stress and development of insulin resistance in adipose, skeletal, liver, and foetoplacental tissue in diabesity

R Villalobos-Labra, M Subiabre, F Toledo… - Molecular aspects of …, 2019 - Elsevier
Diabesity is an abnormal metabolic condition shown by patients with obesity that develop
type 2 diabetes mellitus. Patients with diabesity present with insulin resistance, reduced …

Maternal obesity: new placental paradigms unfolded

C Brombach, W Tong, DA Giussani - Trends in molecular medicine, 2022 - cell.com
The prevalence of maternal obesity is increasing at an alarming rate, and is providing a
major challenge for obstetric practice. Adverse effects on maternal and fetal health are …

Heat shock proteins and their role in pregnancy: Redefining the function of “Old Rum in a New Bottle”

B Jee, R Dhar, S Singh, S Karmakar - Frontiers in Cell and …, 2021 - frontiersin.org
Pregnancy in humans is a multi-step complex physiological process comprising three
discrete events, decidualization, implantation and placentation. Its overall success depends …

Current status of endoplasmic reticulum stress in type II diabetes

S Mustapha, M Mohammed, AK Azemi, AI Jatau… - Molecules, 2021 - mdpi.com
The endoplasmic reticulum (ER) plays a multifunctional role in lipid biosynthesis, calcium
storage, protein folding, and processing. Thus, maintaining ER homeostasis is essential for …

The birth of cardiac disease: Mechanisms linking gestational diabetes mellitus and early onset of cardiovascular disease in offspring

C Tocantins, MS Diniz, LF Grilo… - WIREs mechanisms of …, 2022 - Wiley Online Library
Cardiovascular disease (CVD) is the biggest killer worldwide, composing a major economic
burden for health care systems. Obesity and diabetes are dual epidemics on the rise and …

Exposome and foetoplacental vascular dysfunction in gestational diabetes mellitus

P Valero, G Fuentes, M Cornejo, S Vega… - Molecular Aspects of …, 2022 - Elsevier
A balanced communication between the mother, placenta and foetus is crucial to reach a
successful pregnancy. Several windows of exposure to environmental toxins are present …

ER stress response mediates diabetic microvascular complications

H Sankrityayan, MJ Oza, YA Kulkarni, SR Mulay… - Drug discovery today, 2019 - Elsevier
Highlights•Role of ER stress and autophagy in the pathogenesis of diabetes.•ER stress and
autophagy crucial in diabetic microvascular complications pathogenesis.•Modulation of ER …

[HTML][HTML] Mitochondrial dysfunction in the fetoplacental unit in gestational diabetes mellitus

L Sobrevia, P Valero, A Grismaldo… - … Et Biophysica Acta (BBA …, 2020 - Elsevier
Gestational diabetes mellitus (GDM) is a disease of pregnancy that is associated with d-
glucose intolerance and foeto-placental vascular dysfunction. GMD causes mitochondrial …

Higher gestational weight gain delays wound healing and reduces expression of long non‐coding RNA KLRK1‐AS1 in neonatal endothelial progenitor cells

E Weiss, A Schrüfer, C Tocantins… - The Journal of …, 2023 - Wiley Online Library
High gestational weight gain (GWG) is a cardiovascular risk factor and may disturb neonatal
endothelial function. Long non‐coding RNAs (lncRNAs) regulate gene expression …