Extensive experimental animal studies and epidemiological observations have shown that
environmental influences during early development affect the risk of later pathophysiological …

In the modern world, cardiovascular disease is a leading cause of death for both men and
women. Epidemiologic studies consistently have suggested an association between low …

During the last two decades, there have been several reports of an increasing incidence of
type 2 diabetes mellitus (T2DM) in children and adolescents, especially among those …

We found that the relatively simple microbiota of young infants shifts predictably to a more
mature anaerobic microbiota during infancy and the dynamics of this shift are influenced by …

Importance The opioid epidemic increasingly affects pregnant women and developing
fetuses, resulting in high rates of neonatal abstinence syndrome. However, longitudinal …

Importance Prior studies have raised concern about maternal acetaminophen use during
pregnancy and increased risk of attention-deficit/hyperactivity disorder (ADHD) and autism …

Physiologic adaptations during pregnancy unmask a woman's predisposition to diseases.
Complications are increasingly predicted by first-trimester algorithms, amplify a pre-existing …

Importance Preeclampsia is an independent risk factor for future cardiovascular disease and
disproportionally affects non-Hispanic Black women. The association of maternal nativity …

Background Preeclampsia is a major cause of maternal and fetal morbidity and mortality.
Given its large public health burden, there is a need to identify modifiable factors that can be …

Abstract In1998, the Boston Birth Cohort (BBC) was initiated at Boston Medical Center
(BMC) in response to persistently high rates of preterm birth (PTB, defined as birth before 37 …