An update on African trypanocide pharmaceutics and resistance

KI Kasozi, ET MacLeod, I Ntulume… - Frontiers in Veterinary …, 2022 - frontiersin.org
African trypanosomiasis is associated with Trypanosoma evansi, T. vivax, T. congolense,
and T. brucei pathogens in African animal trypanosomiasis (AAT) while T. b gambiense and …

Metallic nanoparticles and core-shell nanosystems in the treatment, diagnosis, and prevention of parasitic diseases

G Król, K Fortunka, M Majchrzak, E Piktel, P Paprocka… - Pathogens, 2023 - mdpi.com
The usage of nanotechnology in the fight against parasitic diseases is in the early stages of
development, but it brings hopes that this new field will provide a solution to target the early …

Nanotechnology-based strategies in parasitic disease management: from prevention to diagnosis and treatment

R Tiwari, RP Gupta, VK Singh, A Kumar, Rajneesh… - ACS …, 2023 - ACS Publications
Parasitic infections are a major global health issue causing significant mortality and
morbidity. Despite substantial advances in the diagnostics and treatment of these diseases …

Thio- and selenosemicarbazones as antiprotozoal agents against Trypanosoma cruzi and Trichomonas vaginalis

A Ibáñez-Escribano, C Fonseca-Berzal… - Journal of enzyme …, 2022 - Taylor & Francis
Herein, we report the preparation of a panel of Schiff bases analogues as antiprotozoal
agents by modification of the stereoelectronic effects of the substituents on N-1 and N-4 and …

Improving the oral delivery of benznidazole nanoparticles by optimizing the formulation parameters through a design of experiment and optimization strategy

EC Arrua, O Hartwig, B Loretz, H Goicoechea… - Colloids and Surfaces B …, 2022 - Elsevier
Chagas disease is a neglected tropical disease affecting the American continent and also
some regions of Europe. Benznidazole, approved by FDA, is a drug of choice but its poor …

Application of green synthesized nanoparticles in medicinal plant research: Revisiting an emerging eco-friendly approach

S Sena, SJ Ochatt, V Kumar - Plant Cell, Tissue and Organ Culture …, 2023 - Springer
The biogenic production of plant-derived nanoparticles (NPs), with a spotlight on their
potential as eco-friendly sustainable catalysts, is a major topic of study in the field of plant …

Use of Nanocarriers Containing Antitrypanosomal Drugs for the Treatment of Chagas Disease

DF Paiva, APS Matos, DA Garófalo, T do Nascimento… - Pharmaceuticals, 2023 - mdpi.com
Chagas disease, caused by the Trypanosoma cruzi parasitic protozoan, is a neglected
tropical disease (NTD) of significant incidence in Latin America. Transmission to humans …

Anti-trypanosomatid structure-based drug design–lessons learned from targeting the folate pathway

J Panecka-Hofman, I Poehner… - Expert Opinion on Drug …, 2022 - Taylor & Francis
Introduction Trypanosomatidic parasitic infections in humans and animals caused by
Trypanosoma brucei, Trypanosoma cruzi, and Leishmania species pose a significant health …

Gold Nanoparticle-Based Conjugated Nanotags as Potential Compounds against Trypanosoma brucei Infection

S Rostán, S Laing, A Girard, G Scalese… - ACS Applied Nano …, 2024 - ACS Publications
In the search for alternatives for the treatment of parasitic neglected tropical diseases (NTD),
an approach combining metal-based drug design and nanotechnology has been …

Pathogen‐binding nanoparticles to inhibit host cell infection by heparan sulfate and sialic acid dependent viruses and protozoan parasites

A Najer - Smart Medicine, 2024 - Wiley Online Library
Global health faces an immense burden from infectious diseases caused by viruses and
intracellular protozoan parasites such as the coronavirus disease (COVID‐19) and malaria …