Hippocampal sclerosis (HS) is a common pathology encountered in mesial temporal lobe
epilepsy (MTLE) as well as other epilepsy syndromes and in both surgical and post‐mortem …

Epilepsy is the third most common chronic brain disorder, and is characterized by an
enduring predisposition to generate seizures. Despite progress in pharmacological and …

During the last decade, experimental research has demonstrated a prominent role of glial
cells, activated in brain by various injuries, in the mechanisms of seizure precipitation and …

Cytokines are molecules secreted by peripheral immune cells, microglia, astrocytes and
neurons in the central nervous system. Peripheral or central inflammation is characterized …

Highlights•Hyperpolarization-activated cyclic nucleotide-gated (HCN) cation channels are
involved in multiple physiological processes.•HCN channels are excellent targets of various …

Epileptogenesis is defined as the process of developing epilepsy—a disorder characterized
by recurrent seizures—following an initial insult. Seizure incidence during the human …

Recent findings in experimental models and in the clinical setting highlight the possibility
that inflammatory processes in the brain contribute to the etiopathogenesis of seizures and …

This article describes current experimental models of status epilepticus (SE) and neuronal
injury for use in the screening of new therapeutic agents. Epilepsy is a common neurological …

Traumatic brain injury (TBI) is a leading cause of death and disability in young adults
worldwide. TBI survival is associated with persistent neuropsychiatric and neurological …

In recent years, there has been increasing evidence that serotonergic neurotransmission
modulates a wide variety of experimentally induced seizures. Generally, agents that elevate …