Alternative transcription start site usage (ATSS) is a widespread regulatory strategy that
enables genes to choose between multiple genomic loci for initiating transcription. This …

A product of the immediate early gene Arc (Activity-regulated cytoskeleton-associated
protein or Arc protein) of retroviral ancestry resides in the genome of all tetrapods for millions …

Polychlorinated biphenyls (PCBs) are putative environmental risks for neurodevelopmental
disorders. Here, we tested two hypotheses:(1) developmental exposure to a human-relevant …

Angelman syndrome (AS) is a rare neurodevelopmental disorder characterized by impaired
communication skills, ataxia, motor and balance deficits, intellectual disabilities, and …

Many neurodevelopmental disorders (NDDs) are the result of mutations on the X
chromosome. One severe NDD resulting from mutations on the X chromosome is CDKL5 …

Non‐coding DNA (ncDNA) refers to the portion of the genome that does not code for
proteins and accounts for the greatest physical proportion of the human genome. ncDNA …

Angelman syndrome (AS) is a rare genetic neurodevelopmental disorder with profoundly
debilitating symptoms with no FDA-approved cure or therapeutic. Brain-derived neurotrophic …

Disruption of SYNGAP1 directly causes a genetically identifiable neurodevelopmental
disorder (NDD) called SYNGAP1-related intellectual disability (SRID). Without functional …

Brain development is a complex process that requires a series of precise and coordinated
events to take place. When alterations in some of those events occur, neurodevelopmental …

Epilepsy (affects about 70 million people worldwide) is one of the most prevalent brain
disorders and imposes a huge economic burden on society. Epilepsy has a strong genetic …