Site-selective α-C(sp3)–H arylation of dialkylamines via hydrogen atom transfer catalysis-enabled radical aryl migration

J Xu, R Li, Y Ma, J Zhu, C Shen, H Jiang - Nature Communications, 2024 - nature.com
Abstract Site-selective C (sp3)–H arylation is an appealing strategy to synthesize complex
arene structures but remains a challenge facing synthetic chemists. Here we report the use …

Site-selective C (sp3)-H Functionalization of Primary Aliphatic Amines

Y Tao, K Guo, H Chen, G Yan, M Guo - Organic Chemistry Frontiers, 2024 - pubs.rsc.org
The CH bond functionalization represents one of the most efficient and straightforward
strategies to diversify the existing molecules. It is the most challenging task to achieve the …

Organophotocatalytic Selective Deuteration of Metabolically Labile Heteroatom Adjacent C–H Bonds via H/D Exchange with D2O

X Meng, C Che, Y Dong, Q Liu, W Wang - Organic letters, 2024 - ACS Publications
We report a general approach for efficient deuteration of the metabolically labile α-C–H
bonds of widespread amides and amines. Temporarily masking the secondary amine group …

Hydro-and deutero-deamination of primary amines using O-diphenylphosphinylhydroxylamine

P Ma, T Guo, H Lu - Nature Communications, 2024 - nature.com
While selective defunctionalizations are valuable in organic synthesis, hydrodeamination of
primary amines poses challenges. Deuterodeamination, analogous to hydrodeamination …

Multifunctionalization of Alkenyl Alcohols via a Sequential Relay Process

C Liu, L Wang, H Ge - Journal of the American Chemical Society, 2024 - ACS Publications
Aryl-substituted aliphatic amines are widely recognized as immensely valuable molecules.
Consequently, the development of practical strategies for the construction of these …

dn-Alkyl Phosphonium Iodide Salts as Radical dn-Alkylating Reagents and Their Applications in the Photoinduced Synthesis of dn-Alkylated Heterocycles

Q Liu, XD Su, BB Zhang, HR Kong, YL Tu… - CCS …, 2024 - chinesechemsoc.org
Deuteration, using diverse, readily accessible deuterium reagents, has recently emerged as
a powerful tool for achieving high deuterium content with precise positional control …

Photocatalytic Multiple Deuteration of Polyethylene Glycol Derivatives using Deuterium Oxide

R Ogasahara, M Mae, K Matsuura… - … A European Journal, 2024 - Wiley Online Library
Deuterated molecules are of growing interest because of the specific characteristics of
deuterium, such as stronger C‐D bonds being stronger than C‐H bonds. Polyethylene …