Drugs for treating infections caused by non-tubercular mycobacteria: a narrative review from the study group on mycobacteria of the Italian Society of Infectious …

A Calcagno, N Coppola, L Sarmati, M Tadolini… - Infection, 2024 - Springer
Background Non-tuberculous mycobacteria (NTM) are generally free-living organism, widely
distributed in the environment, with sporadic potential to infect. In recent years, there has …

阿米卡星在老年肾功能不全患者中生理药动学模型的建立与应用

李乔希, 管宴萍, 夏晨, 吴莉莉, 王妍 - 中国药房, 2023 - journal.china-pharmacy.com
目的建立阿米卡星在老年肾功能不全患者中的生理药动学(PBPK) 模型. 方法使用PK-SIM®
软件进行模型的构建, 拟合和模拟. 通过查询文献资料, 收集阿米卡星的理化性质和体内药动学 …

Prediction of tissue exposures of polymyxin-B, amikacin and sulbactam using physiologically-based pharmacokinetic modeling

M Wu, K Feng, X Wu, C Liu, S Zhu, FS Martins… - Frontiers in …, 2024 - frontiersin.org
Background The combination antimicrobial therapy consisting of amikacin, polymyxin-B, and
sulbactam demonstrated in vitro synergy against multi-drug resistant Acinetobacter …

基于PPK 辅助决策系统JPKD 优化阿米卡星固定日剂量给药方案

朱裕林, 高山, 侯婷婷, 洪磊, 蒋安帮… - 中国临床药理学与 …, 2024 - manu41.magtech.com.cn
目的: 考察群体药代动力学(PPK) 软件JPKD 对阿米卡星稳态浓度的预测性能, 推荐400 mg
和600 mg 固定日剂量的适用条件. 方法: 选取2022 年7 月至2024 年2 月蚌埠医科大学第一附属 …

Side effects of miscellaneous antibiotics

E Samuel, JD McCanless, Z Saadut… - Side Effects of Drugs …, 2024 - books.google.com
Antibiotics have been utilized for the past several decades (Wall & Maxwell, 2021) for the
treatment of var-ious infections and have had a significant impact on morbidity and mortality …

Dose Optimization of Amikacin in the Emergency Department: A Population Pharmacokinetics Simulation Study

N Dia, S De Winter, M Gijsen, S Desmet… - Therapeutic Drug …, 2022 - journals.lww.com
Background: In adult patients with sepsis or septic shock admitted to the emergency
department, a single intravenous 15 mg/kg amikacin dose provides inadequate …

Optimisation of fixed daily dose regimens for amikacin based on PPK auxiliary system of JPKD

Y ZHU, S GAO, T HOU, L HONG… - Chinese Journal of …, 2024 - manu41.magtech.com.cn
AIM: To examine the predictive performance of the PPK software JPKD for the steady-state
concentrations of amikacin and recommend the applicable conditions under fixed daily …

Establishment and application of the physiologically-based pharmacokinetic model of amikacin in elderly patients with renal insufficiency

Q LI, Y Guan, C Xia, L WU, Y Wang - China Pharmacy, 2023 - pesquisa.bvsalud.org
OBJECTIVE To establish a physiologically-based pharmacokinetic (PBPK) model of
amikacin in elderly patients with renal insufficiency. METHODS PK-SIM® software was …