Impact of sharing Alzheimer's disease biomarkers with individuals without dementia: a systematic review and meta‐analysis of empirical data

J van der Schaar, LNC Visser, JCF Ket… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction We conducted a systematic literature review and meta‐analysis of empirical
evidence on expected and experienced implications of sharing Alzheimer's disease (AD) …

Alzheimer's disease risk reduction in clinical practice: a priority in the emerging field of preventive neurology

K Niotis, C Saperia, N Saif, C Carlton… - Nature Mental …, 2024 - nature.com
Alzheimer's disease is increasing in prevalence disproportionately to longevity, placing
enormous burden on individuals, families, healthcare systems and the economy …

Clinical effect of early vs late amyloid positron emission tomography in memory clinic patients: the AMYPAD-DPMS randomized clinical trial

D Altomare, F Barkhof, C Caprioglio, LE Collij… - JAMA …, 2023 - jamanetwork.com
Importance Amyloid positron emission tomography (PET) allows the direct assessment of
amyloid deposition, one of the main hallmarks of Alzheimer disease. However, this …

Personal value of Alzheimer's disease biomarker testing and result disclosure from the patient and care partner perspective

KJ Patel, D Yang, HH Feldman… - … Research & Clinical …, 2024 - Wiley Online Library
INTRODUCTION We described patients' and care partners' experiences with Alzheimer's
disease (AD) cerebrospinal fluid (CSF) biomarker testing and result disclosure in routine …

Research Participants' Perspectives on Precision Diagnostics for Alzheimer's Disease

HS Smith, JO Robinson, A Levchenko… - Journal of …, 2024 - content.iospress.com
Background: Understanding research participants' responses to learning Alzheimer's
disease (AD) risk information is important to inform clinical implementation of precision …

Association of amyloid-beta with depression or depressive symptoms in older adults without dementia: a systematic review and meta-analysis

EL Twait, JH Wu, M Kamarioti, M Basten… - Translational …, 2024 - nature.com
Several lines of evidence have indicated that depression might be a prodromal symptom of
Alzheimer's disease (AD). This systematic review and meta-analysis investigated the cross …

Psychosocial and Behavioral Outcomes for Persons With Cognitive Impairment and Caregivers Following Amyloid-β PET Scan Disclosure: A Systematic Review

E Couch, MT Ashford, W Zhang… - Alzheimer Disease & …, 2023 - journals.lww.com
Background: Positron emission tomography (PET) scans for amyloid-β can aid in the early
and accurate detection of Alzheimer disease. The results of amyloid PET scans could help …

A pragmatic, investigator-driven process for disclosure of amyloid PET scan results to ADNI-4 research participants

CM Erickson, J Karlawish, JD Grill, K Harkins… - The journal of …, 2024 - Springer
Abstract Background Prior studies of Alzheimer's disease (AD) biomarker disclosure have
answered important questions about individuals' safety after learning and comprehending …

Immediate Reactions to Alzheimer Biomarker Disclosure in Cognitively Unimpaired Individuals in a Global Truncated Randomized Trial

JD Grill, R Raman, K Ernstrom, S Wang… - Neurology: Clinical …, 2024 - AAN Enterprises
Background and Objectives Preclinical Alzheimer disease (AD) trials simultaneously test
candidate treatments and the implications of disclosing biomarker information to cognitively …

Clinical Practice in the Alzheimer Biomarker Era—Drugs for the Brain and Care for the Mind

J Karlawish - JAMA network open, 2023 - jamanetwork.com
Alzheimer disease, unlike conditions like hypertension, must speak to be diagnosed. For
much of the 20th century, diagnosis required a person to recount a story of their own or their …