Aging is a major risk factor for cancer development. As dysfunction in protein homeostasis,
or proteostasis, is a universal hallmark of both the aging process and cancer, a …

The goal of cancer research is to identify characteristics of cancer cells that allow them to be
selectively eliminated without harming the host. One such characteristic is autophagy …

The initiation and progression of colorectal cancer (CRC) are intimately associated with
genetic, environmental and biological factors. Desulfovibrio vulgaris (DSV), a sulfate …

Proteolysis targeting chimera (PROTAC) technology represents a groundbreaking
development in drug discovery, leveraging the ubiquitin‒proteasome system to specifically …

Phosphoinositides serve as essential players in numerous biological activities and are
critical for overall cellular function. Due to their complex chemical structures, localization …

The urological system, including kidneys, ureters, bladder, urethra and prostate is known to
be vital for blood filtration, waste elimination and electrolyte balance. Notably, urological …

The phosphoinositide kinase, PIKfyve is a lipid kinase that plays a vital role in membrane
trafficking, endosomal transport, retroviral budding, and toll-like receptor signaling. Thus, it …

Pancreatic ductal adenocarcinoma (PDAC) subsists in a nutrient-deregulated
microenvironment, making it particularly susceptible to treatments that interfere with cancer …

Pancreatic ductal adenocarcinoma (PDAC) is characterized by KRAS-and
autophagydependent growth. We and others previously demonstrated that inhibition of the …