Thiadiazole—A promising structure in medicinal chemistry

Y Li, J Geng, Y Liu, S Yu, G Zhao - ChemMedChem, 2013 - Wiley Online Library
Many compounds containing a five‐membered heterocyclic ring display exceptional
chemical properties and versatile biological activities. In this Minireview, thiadiazoles are …

[HTML][HTML] Green chemistry in organic synthesis: Recent update on green catalytic approaches in synthesis of 1, 2, 4-thiadiazoles

L Rubab, A Anum, SA Al-Hussain, A Irfan, S Ahmad… - Catalysts, 2022 - mdpi.com
Green (sustainable) chemistry provides a framework for chemists, pharmacists, medicinal
chemists and chemical engineers to design processes, protocols and synthetic …

Design, synthesis and ADMET prediction of bis-benzimidazole as anticancer agent

M Rashid - Bioorganic chemistry, 2020 - Elsevier
A new series of bis-benzimidazole clubbed with primary amine (3i-iii) and aromatic
aldehydes (4i-ix) were design and synthesize with an intention to search an anticancer lead …

Synthesis and anticancer activity of 5-(3-indolyl)-1, 3, 4-thiadiazoles

D Kumar, NM Kumar, KH Chang, K Shah - European journal of medicinal …, 2010 - Elsevier
A series of 5-(3-indolyl)-2-substituted-1, 3, 4-thiadiazoles 5a–m were synthesized and their
cytotoxicity analyzed against six human cancer cell lines. The reaction of indole-3-carboxylic …

A comprehensive review of N-heterocycles as cytotoxic agents

D Kumar, S Kumar Jain - Current Medicinal Chemistry, 2016 - ingentaconnect.com
Scientific community is striving to understand the role of heterocycles and fused
heterocycles in drug discovery programme due to its impact on multi-drug resistance (MDR) …

Design, synthesis, and biological evaluation of triazolone derivatives as potent PPARα/δ dual agonists for the treatment of nonalcoholic steatohepatitis

Z Feng, J Xiang, H Liu, J Li, X Xu, G Sun… - Journal of Medicinal …, 2022 - ACS Publications
Peroxisome proliferator-activator receptors α/δ (PPARα/δ) are regarded as potential
therapeutic targets for nonalcoholic steatohepatitis (NASH). However, PPARα/δ dual agonist …

Peroxisome proliferators‐activated receptor (PPAR) modulators and metabolic disorders

MC Cho, K Lee, SG Paik, DY Yoon - PPAR research, 2008 - Wiley Online Library
Overweight and obesity lead to an increased risk for metabolic disorders such as impaired
glucose regulation/insulin resistance, dyslipidemia, and hypertension. Several molecular …

Novel 1, 3, 4-heterodiazole analogues: synthesis and in-vitro antitumor activity

AT Taher, HH Georgey, HI El-Subbagh - European journal of medicinal …, 2012 - Elsevier
The synthesis of some new heterodiazole and their annulated imidazo [2, 1-b] 1, 3, 4-
oxa/thiadiazolone 6a–d, 7a–d; 1, 3, 4-oxa or thiadiazole [3, 2-a] pyrimidine diamine 8a–d …

Eosin Y catalyzed visible-light-driven aerobic oxidative cyclization of thioamides to 1, 2, 4-thiadiazoles

VP Srivastava, AK Yadav, LDS Yadav - Synlett, 2013 - thieme-connect.com
A new approach for an efficient metal-free synthesis of 1, 2, 4-thiadiazoles from primary
thioamides using visible light and air in the presence of eosin Y as a photoredox catalyst is …

Building 1, 2, 4‐Thiadiazole: Ten Years of Progress

LMT Frija, AJL Pombeiro… - European Journal of …, 2017 - Wiley Online Library
Thiadiazoles are among the privileged pharmacological building blocks due to their unique
chemical properties for diverse biological and clinical applications. 1, 2, 4‐Thiadiazole …