[HTML][HTML] The ACE2/angiotensin-(1–7)/MAS axis of the renin-angiotensin system: focus on angiotensin-(1–7)

RAS Santos, WO Sampaio, AC Alzamora… - Physiological …, 2017 - journals.physiology.org
The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular
system and hydroelectrolyte balance, with an influence on organs and functions throughout …

ACE2, angiotensin‐(1‐7) and M as receptor axis in inflammation and fibrosis

AC Simões e Silva, KD Silveira… - British journal of …, 2013 - Wiley Online Library
Recent advances have improved our understanding of the renin‐angiotensin system (RAS).
These have included the recognition that angiotensin (A ng)‐(1‐7) is a biologically active …

Angiotensin-(1–7)

RA Santos - Hypertension, 2014 - Am Heart Assoc
Santos Cardiovascular Actions of Angiotensin-(1–7) 1139 in caveolin 3 expression and a
decrease in heat shock protein 90. 28 These 2 alterations may lead to a decrease in eNOS …

Tissue renin-angiotensin-aldosterone systems: Targets for pharmacological therapy

M Bader - Annual review of pharmacology and toxicology, 2010 - annualreviews.org
The renin-angiotensin-aldosterone system is one of the most important systems in
cardiovascular control and in the pathogenesis of cardiovascular diseases. Therefore, it is …

Angiotensin-converting enzyme II in the heart and the kidney

U Danilczyk, JM Penninger - Circulation research, 2006 - Am Heart Assoc
The renin-angiotensin system (RAS) has been recognized for many years as critical
pathway for blood pressure control and kidney functions. Although most of the well-known …

The role of ACE2 in cardiovascular physiology

GY Oudit, MA Crackower, PH Backx… - Trends in cardiovascular …, 2003 - Elsevier
The renin–angiotensin system (RAS) is critically involved in cardiovascular and renal
function and in disease conditions, and has been shown to be a far more complex system …

Angiotensin-(1-7) counterregulates angiotensin II signaling in human endothelial cells

WO Sampaio, C Henrique de Castro, RAS Santos… - …, 2007 - Am Heart Assoc
Angiotensin (Ang)-(1-7), acting through the Mas receptor, opposes the actions of Ang II.
Molecular mechanisms for this are unclear. Here we sought to determine whether Ang-(1-7) …

Peptide hormone regulation of angiogenesis

C Clapp, S Thebault, MC Jeziorski… - Physiological …, 2009 - journals.physiology.org
It is now apparent that regulation of blood vessel growth contributes to the classical actions
of hormones on development, growth, and reproduction. Endothelial cells are ideally …

Novel peptide inhibitors of angiotensin-converting enzyme 2

L Huang, DJ Sexton, K Skogerson, M Devlin… - Journal of Biological …, 2003 - ASBMB
Angiotensin-converting enzyme 2 (ACE2), a recently identified human homolog of ACE, is a
novel metallocarboxypeptidase with specificity, tissue distribution, and function distinct from …

The link between adipose tissue renin-angiotensin-aldosterone system signaling and obesity-associated hypertension

MTJ Schütten, AJHM Houben, PW de Leeuw… - …, 2017 - journals.physiology.org
Obese individuals frequently develop hypertension, which is for an important part
attributable to renin-angiotensin-aldosterone system (RAAS) overactivity. This review …