[PDF][PDF] Diagnosing diabetic neuropathy: something old, something new

IN Petropoulos, G Ponirakis, A Khan… - Diabetes & …, 2018 - synapse.koreamed.org
There are potentially many ways of assessing diabetic peripheral neuropathy (DPN).
However, they do not fulfill US Food and Drug Administration (FDA) requirements in relation …

Corneal confocal microscopy: ready for prime time

IN Petropoulos, G Ponirakis, A Khan… - Clinical and …, 2020 - Taylor & Francis
Corneal confocal microscopy is a non‐invasive ophthalmic imaging modality, which was
initially used for the diagnosis and management of corneal diseases. However, over the last …

[HTML][HTML] Corneal confocal microscopy: a biomarker for diabetic peripheral neuropathy

IN Petropoulos, G Ponirakis, M Ferdousi, S Azmi… - Clinical …, 2021 - Elsevier
Purpose Diagnosing early diabetic peripheral neuropathy remains a challenge due to
deficiencies in currently advocated end points. The cornea is densely innervated with small …

Corneal nerve fractal dimension: a novel corneal nerve metric for the diagnosis of diabetic sensorimotor polyneuropathy

X Chen, J Graham, IN Petropoulos… - … & Visual Science, 2018 - iovs.arvojournals.org
Objective: Corneal confocal microscopy (CCM), an in vivo ophthalmic imaging modality, is a
noninvasive and objective imaging biomarker for identifying small nerve fiber damage. We …

Corneal confocal microscopy detects corneal nerve damage and increased dendritic cells in Fabry disease

G Bitirgen, K Turkmen, RA Malik, A Ozkagnici… - Scientific Reports, 2018 - nature.com
Fabry disease is characterised by neuropathic pain and accelerated vascular disease. This
study evaluates the utility of corneal confocal microscopy (CCM) to non-invasively quantify …

Corneal keratocyte density and corneal nerves are reduced in patients with severe obesity and improve after bariatric surgery

Z Iqbal, A Kalteniece, M Ferdousi… - … & Visual Science, 2021 - iovs.arvojournals.org
Purpose: Obesity is associated with peripheral neuropathy, which bariatric surgery may
ameliorate. The aim of this study was to assess whether corneal confocal microscopy can …

Potential use of corneal confocal microscopy in the diagnosis of Parkinson's disease associated neuropathy

NN Che, HQ Yang - Translational Neurodegeneration, 2020 - Springer
Parkinson's disease (PD) is a chronic, progressive neurodegenerative disease affecting
about 2–3% of population above the age of 65. In recent years, Parkinson's research has …

Corneal confocal microscopy: Neurologic disease biomarker in Friedreich ataxia

OE Pagovich, ML Vo, ZZ Zhao… - Annals of …, 2018 - Wiley Online Library
Objective Friedreich ataxia (FRDA), an autosomal recessive neurodegenerative disease
caused by mutations in the gene encoding for the mitochondrial protein frataxin, is …

Corneal confocal microscopy detects a reduction in corneal endothelial cells and nerve fibres in patients with acute ischemic stroke

A Khan, S Kamran, N Akhtar, G Ponirakis… - SCIENtIfIC …, 2018 - nature.com
Endothelial dysfunction and damage underlie cerebrovascular disease and ischemic stroke.
We undertook corneal confocal microscopy (CCM) to quantify corneal endothelial cell and …

Computational methods for automated analysis of corneal nerve images: Lessons learned from retinal fundus image analysis

T Salahuddin, U Qidwai - Computers in Biology and Medicine, 2020 - Elsevier
Corneal and retinal imaging provide a descriptive view of the nerve and vessel structure
present inside the human eye, in a non-invasive manner. This helps in ocular, or other …