Orthologs of the pentameric receptor channels that mediate fast synaptic transmission in the
central and peripheral nervous systems have been found in several bacterial species and in …

Solid phase peptide synthesis (SPPS) provides the possibility to chemically synthesize
peptides and proteins. Applying the method on hydrophilic structures is usually without …

The superfamily of pentameric ligand-gated ion channels (pLGICs) comprises key players in
electrochemical signal transduction across evolution, including historic model systems for …

The nicotinic acetylcholine receptor (nAChR) is a transmembrane protein that mediates fast
intercellular communication in response to the endogenous neurotransmitter acetylcholine …

Membrane lipids are potent modulators of the nicotinic acetylcholine receptor (nAChR) from
Torpedo. Lipids influence nAChR function by both conformational selection and kinetic …

Signals between a cell and its environment are often transmitted through membrane
proteins; therefore, many membrane proteins, including G protein-coupled receptors …

Pentameric ligand-gated ion channels are activated by the binding of agonists to a site
distant from the ion conduction path. These membrane proteins consist of distinct ligand …

The α7 nicotinic acetylcholine receptor (nAChR), assembled as homomeric pentameric
ligand-gated ion channels, is one of the most abundant nAChR subtypes in the brain …

Membrane proteins have always presented technical challenges for structural studies
because of their requirement for a lipid environment. Multiple approaches exist including X …

The abuse or misuse of antibiotics has caused the emergence of extensively drug-resistant
(XDR) bacteria, rendering most antibiotics ineffective and increasing the mortality rate of …